- Risk for death from colorectal cancer reduced by 17 percent.
- Allergy-related immune system responses could be potential mechanisms.
“Having both of these conditions could indicate that you are more likely to develop allergy-related immune responses that lower your risk for developing fatal colorectal cancer,” said Eric Jacobs, Ph.D., strategic director of pharmacoepidemiology at the American Cancer Society.
In an earlier study published in 2005, researchers examined data from the Cancer Prevention Study II (CPS-II), a large prospective study of more than 1 million U.S. men and women who had been followed from 1982 to 2000. Results from this initial study showed that participants with both hay fever and asthma were at lower risk for developing fatal colorectal cancer.
In the current study, researchers looked again at data from the more than 1 million participants in CPS-II who did not have cancer at the start of the study and were followed through 2008. They also examined data from the Cancer Prevention Study I, a similarly sized study, in which participants were followed from 1959 to 1972.
The combined results from the CPS-I and CPS-II studies, including more than 19,000 deaths from colorectal cancer, confirmed the findings from the earlier study: People with hay fever and asthma had an approximately 17 percent lower risk for dying from colorectal cancer. People with only hay fever or only asthma had little reduction in risk for fatal colorectal cancer.
Jacobs and colleagues believe that the lower risk for fatal colorectal cancer among people with both hay fever and asthma may be a result of atopy, which is the general predisposition to develop allergic responses, including those that cause allergies and asthma. According to Jacobs, it is possible that individuals with atopy may sometimes mount an allergic-like response against colon cancer cells as well.
Future research could evaluate whether an association exists between other measures of atopy, such as blood levels of the immunoglobulin E antibody, and risk for developing or dying from colorectal cancer. If such an association is found, there could be implications for development of vaccines to stimulate anticancer immune responses in patients with colorectal cancer.
“If allergy-related immune responses are lowering colorectal cancer mortality in some individuals, that would imply that a similar kind of response might be inducible by a vaccine,” Jacobs said.
About the American Association for Cancer Research
Founded in 1907, the American Association for Cancer Research (AACR) is the world’s first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the scientific partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of team science and individual grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.
For more information about the AACR, visit www.AACR.org.
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