03:05pm Monday 24 February 2020

Multidisciplinary research describes anti-tumour response to vaccine being developed for treating cancer of the cervix

The research, in which the Applied Medicine Research Centre (Gene Therapy and Hepatology Division) cooperated, was carried out using pharmacokinetic –pharmacodynamic techniques, employing experimental data from mice models.

According to the author of the research, Ms. Zinnia Parra-Guillén, from the Pharmacometrics Group at the Hospital’s Department of Pharmacy and Pharmaceutics Technology, “this type of measurement enables anticipating clinical results amongst humans, the principal goal of the translational research, and thus contributes to reducing the high rate of failure in the late stages of developing new pharmaceutical drugs. Also, on being able to develop them “in silica”, i.e. through computer simulation, savings in costs and time have been made possible”, she stressed.


The aim of the research was to show the great potential of the incorporation of models (kinetic and dynamic) during the initial stages of developing the various therapeutic proteins and products of gene therapy.


The model interprets complex biological information


The importance of the pharmacokinetic–pharmacodynamic model in the field of experimental and applied pharmacology lies in the fact that it enables analysing complex information in a comprehensive way, and obtained at various levels (gene expression, concentration of pharmaceutical drug in different organs, etc.), thus providing a better understanding of the system being studied. Nevertheless, as the Doctor explained, “its application in biotechnological products, a relatively new area but a growing one, is still limited, especially during the initial stages of its preclinical development”.


The PhD by Ms. Zinnia won a European doctorate and one of its illustrations was chosen to adorn the front cover of the September issue of the Journal of Pharmacology and Experimental Therapeutics, journal of reference in the area of pharmacology and pharmacy.

lhuyar Fundazioa

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