06:51pm Friday 10 July 2020

Sun powers complex cancer test for remote regions

Dr. Ethel Cesarman

By harnessing the sun’s power and employing a smartphone application, medical technicians may now handily administer reliable assays for Kaposi’s sarcoma, which has produced significant morbidity and mortality rates among adults and children in sub-Saharan Africa. The researchers described the technology on Feb. 20 in Scientific Reports, an online publication of Nature.

“Mortality in sub-Saharan Africa following a Kaposi’s sarcoma diagnosis is unacceptably high, even after introduction of antiretroviral therapies. This is partly due to the difficulty of making an accurate diagnosis with current technologies, which results in delayed treatment and advanced disease, which is difficult to treat,” said Dr. Ethel Cesarman, professor of pathology and laboratory medicine at Weill Cornell Medical College.

This Cornell-developed solar thermal PCR (polymerase chain reaction) test for a smartphone uses about 80 milliwatts — or .08 watts — which means that a standard smartphone battery could provide about 70 hours of power for testing. With this system, medical technicians can obtain human skin biopsies, deposit the biopsied material into the solar thermal PCR device and obtain completed diagnostic tests with a smartphone in less than 30 minutes.

“We believe that exploiting the ubiquity of solar thermal energy — as demonstrated here — could facilitate broad availability of nucleic-based diagnostics in resource-limited areas,” said first author Li Jiang, a doctoral candidate in Cornell’s Sibley School of Mechanical and Aerospace Engineering.

The thermal-cycling process needed for DNA amplification typically requires ample energy to process biopsies, including steps such as denaturation (breaking down nucleic acid structures), extension (duplicating the DNA chain) and annealing (recombining the DNA material). Solar thermal DNA amplification — which the Cornell group devised and that is the size of a lunchbox — removes the power requirements for thermal cycling and enables a 100-fold reduction in power consumption compared with state-of- the-art, Western devices.

“DNA tests are extensively used in medical diagnostics since they are sensitive and specific. Some places in the developing world have limited infrastructure and unreliable electricity, and these kinds of tests usually hog energy,” said David Erickson, Cornell professor of mechanical and aerospace engineering.

Using the Cornell group’s technology, Dr. Cesarman says, “Tests can be performed in less than a half hour, potentially enabling rapid diagnostics where long travel distances to clinics make follow-up meetings with patients difficult.”

A version of this story ran in the Cornell Chronicle.

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