10:27pm Sunday 05 July 2020

Bacteria may enhance the body’s ability to fight melanoma

The research published in the official journal of the American Association of Immunologists, the Journal of Immunology, demonstrates that bacteria stimulate a type of immune response that results in more effective killer cell attacks against cancer.

A McLellanAssociate Professor Alex McLellan

Associate Professor Alex McLellan from the Department of Microbiology and Immunology says the new results are very encouraging and will prompt further investigation using human cells and cancer patients.

“By using bacteria we can excite an immune response against cancer and our results show that natural killer cells are very important in this enhanced response,” Dr McLellan explains.

“What we’ve discovered is that these natural killer cells are stimulated by bacteria to enhance the potency of the immune response to the tumour. Interestingly, natural killer cells don’t seem to make the vaccine any stronger, but rather enhance the visibility of the tumour to the immune response induced by vaccination.”

Associate Professor McLellan says that this pathway further enhances the body’s ability to attack cancer cells by boosting tumour-specific T cells. The natural killer cells seem to be releasing growth factors which make other immune cell types better able to destroy the cancer.

Vaccination predominantly stimulates an ‘adaptive’ immune response. Since natural killer cells were initially classed as members of the innate, or primitive, arm of the immune system, they were thought to play no part in protection afforded by vaccination. But this research shows important links between the innate and adaptive response of the body in anti-tumour immunity, says Dr McLellan.

An immunological approach to cancer harks back to over 120 years ago to Coley’s toxins, says Dr McLellan. American surgeon William Coley discovered in the 1890s that when a patient is inoculated or even infected with bacteria this can have a significant effect or even destroy the cancer. This approach was not seriously pursued after the development of chemotherapy and radiation.

Now this area of research is again being reactivated as another possible tool in the fight against cancer.

Associate Professor McLellan says the next step is to test these very positive findings using human cells, and then extend it to cancer patients through collaborators in Germany.

This research has been funded by University of Otago.

 

For further information contact

Associate Professor Alex McLellan
Department of Microbiology and Immunology
University of Otago
Tel 64 3 479 7728


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