08:06pm Tuesday 12 December 2017

Research in the News: Yale team devises ingenious method to attack cancer at its genetic source

However, their potential as a target for cancer therapy has not been realized because of a daunting problem that has held back clinical applications of gene therapy: How can you target minute pieces of genetic material locked safely inside the membranes of billions of cells?

Now a multi-disciplinary team of Yale researchers has solved the problem by designing a therapeutic molecule that both targets the acidic microenvironments of tumors and penetrates cells to deliver a therapeutic cargo. The new delivery system effectively killed advanced tumors in mice, the team reports in the Nov. 17 issue of the journal Nature.

“This strategy opens up a new pathway to therapy, not just for the treatment of cancer but for a host of other diseases as well,” said Donald Engelman, a co-author of the paper and the Eugene Higgins Professor of Molecular Biophysics and Biochemistry at Yale. 

The findings were result of an extensive collaboration between labs of Engelman, Peter Glazer, Mark Saltzman and Frank Slack.

Contact
Bill Hathaway
william.hathaway@yale.edu
203-432-1322


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