07:24am Thursday 19 October 2017

From Heart Attacks to Cancer: What Role Do Long, Non-Coding RNAs Play?

FRANKFURT. About 70 percent of our genes provide the blueprint for biomolecules whose function is only now being discovered – non-coding RNAs. Instead of being translated into proteins, they seem to perform steering functions in the body. Stefanie Dimmeler was one of the first researchers to prove that the sub-group of micro-RNAs plays a role in regenerating blood vessels. She has now received the coveted ERC Advanced Investigator Grant from the European Research Council (ERC), which will allow her to study another large group of non-coding RNAs. She believes that this group plays a role in creating heart attacks, strokes and cancer. ERC has awarded her 2.5 million Euros over the next five years.

“If you asked me what was special about the evolutionary development of human beings, I would say it´s the more than 30,000 non-coding RNA, most of which we only share with primates,” says Stefanie Dimmeler. From the perspective of her research area, cardiovascular regeneration, it is especially noteworthy that vascular illnesses like arteriosclerosis, which causes heart attacks, only occur in their typical form in humans. There are many indicators that long, non-coding RNAs, lncRNAs for short, control these illnesses. They affect the inside layer of the blood vessels, known as endothelial cells, and help supply the organs and tissues with oxygen and nutrients.

The technologies used to track these lncRNAs and their complex functions are much more complicated than finding proteins. Dimmeler and her working group identified two candidates, Angiolnc1 and Angiolnc2, that regulate the functions of endothelial cells. Now she wants to study the molecular epigenetic mechanisms that these two lncRNAs use to trigger vascular illnesses. The goal of this research is to identify new treatments for preventing arteriosclerosis, in order to reduce the incidence of heart attacks and strokes.

In the third part of her project, Dimmeler will study whether ring-shaped lncRNAs, which have special protection once they are released into the blood, can be used as biomarkers for identifying illnesses in the vascular system or the heart. To this end, she will work with her group to develop tests that can be used to find these biomolecules in patients’ blood during the various stages of cardiovascular illnesses.

Prof. Stefanie Dimmeler, born in 1967, studied Biology at the University of Constance, where she received her doctorate in 1993. After two years as a research assistant at the University of Cologne, she went to Goethe University, where she was promoted to professor in 1998 in the Department of Experimental Medicine. In 2001, she accepted a position as a professor in the Molecular Cardiology Department at Goethe University. She has been the Director of the Institute of Cardiovascular Regeneration, in the Center for Molecular Medicine, since 2008. She is the co-speaker of the DFG-funded “Cardiopulmonary Systems” Excellence Cluster, the “LOEWE Center for Cell and Genetic Therapy” funded by the State of Hesse, and the German Center for Cardiovascular Research (DZHK) funded by the German Ministry for Education and Research (BMBF) at the Rhine-Main site. She is a member of the Macromolecular Complexes Excellence Cluster as well as several specialized research areas. From 2008 to 2012, she was a member of the German Ethics Commission. Stefanie Dimmeler has received numerous research prizes, including the renowned Gottfried Wilhelm Leibniz Prize from the German Research Foundation and the Ernst Jung Prize for Medicine.

Pictures are available for download here: www.uni-frankfurt.de/55538604


Prof. Stefanie Dimmeler.

Blood vessels: An image of blood vessels in the heart (shown in red). The large vessel is surrounded by smaller vessels (capillaries). The nuclei are shown in blue, and the neurons are green.

Information:  Prof. Stefanie Dimmeler, Institute for Cardiovascular Regeneration, Niederrad Campus, Main Office: Claudia Herfurth, Tel.: (069) 6301-6667, herfurth@med.uni-frankfurt.de.

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