Allogeneic hematopoietic stem cell transplantation (HSCT) involves the transplantation of stem cells from a donor, which may be derived from bone marrow, peripheral blood or umbilical cord blood. The recipient’s immune system is usually destroyed with radiation or chemotherapy before the transplantation. It is the only reported cure for JMML; however best outcomes of the therapy have shown only that half of patients can be cured from their disease. According to the researchers, there is currently no standard conditioning regimen for children with JMML undergoing HSCT.
The CHLA study, led by Hisham Abdel-Azim, MD, looked at children with JMML who underwent HSCT at Children’s Hospital Los Angeles. All of the patients were alive and in clinical remission.
“The lack of transplant-related mortality in the group of children we studied at the Children’s Center for Cancer and Blood Diseases at CHLA suggests that BUMEL (Intravenous Busulfan and Melphalan) may represent a successful HSCT high-dose chemotherapy regimen,” said Abdel-Azim. “It is also possible that administering conventional dose chemotherapy, before HSCT, to patients with more progressive disease may have contributed to the improved outcomes.”
He added that a follow up clinical trial is warranted to confirm these promising findings, which are published in the July 23, 2015, issue of the journal Blood.
About Children’s Hospital Los Angeles
Children’s Hospital Los Angeles has been named the best children’s hospital in California and among the top 10 in the nation for clinical excellence with its selection to the prestigious U.S. News & World Report Honor Roll. Children’s Hospital is home to The Saban Research Institute, one of the largest and most productive pediatric research facilities in the United States. Children’s Hospital is also one of America’s premier teaching hospitals through its affiliation since 1932 with the Keck School of Medicine of the University of Southern California. For more information, CHLA.org. Follow us on Twitter, Facebook, YouTube and LinkedIn, or visit our blog: ResearCHLAblog.org
Media contact: Debra Kain, firstname.lastname@example.org, 323-361-7628 or 323-361-1812