02:05am Thursday 19 October 2017

A new use for older drugs to target the spread of breast cancer

Carol Williams, PhD, professor of pharmacology and toxicology at MCW, is the primary investigator of the grant.

Dr. Williams previously made a discovery that activation of a large family of molecules called G protein-coupled receptors (GPCRs) are key in the transformation, growth and spread of breast cancer cells. Inhibiting those GPCRs should shut down the signaling of a protein that drives the spread, or metastasis, of breast cancer tumor cells.

In this project, Dr. Williams and her co-investigators will work to develop an innovative strategy to inhibit breast cancer metastasis by repurposing existing medications that target GPCRs—but which are not currently used to treat cancers. The proposed research will provide significant benefits by developing an innovative strategy to inhibit breast cancer metastasis. 

Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
(414) 955-8296


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