09:58pm Monday 21 August 2017

Important step breast cancer research Universiteit Twente

The technique, which was christened PAMmografie, uses short pulses of light that cause ultrasound in places where there is a lot of blood, such as around malignant tumors. With a publication in the journal Scientific Reports present the researchers an important scientific step for the study. They showed that there are several distinct forms of breast tumors with their technique.

 Almost fifteen years ago, researchers at the University of Twente starts continued the search for a new method to detect breast cancer. This has led to a so-called PAMmoscoop; a device developed by the UT that the breast illuminated with short light pulses which cause ultrasound in places where there is a lot of blood, such as around malignant tumors. This ultrasound then travels to the skin surface, where you can measure it.

New research

By bringing a new study published by the journal Scientific Reports, the researchers show that their method does have potential in the future, in practice breast tumors into the picture. It’s the first demand-driven research in this field. The researchers have, simply put, were analyzed in a cohort of 32 patients how different breast tumors look at their method. In the publication, they compare these views with MRI images and images with which the tumor after removal is stained with a dye. The researchers were able to distinguish three different forms of the tumors. According to Associate Professor Manohar, one of the researchers involved, this is an important step for diagnostic indicators – thus ways to identify a tumor on a PAMmografiebeeld – declare.

According to Manohar PAMmografie scores well in the survey compared to MRI and shows the research PAMmografie definitely has potential to be used later in practice. Especially because the technique has several important advantages. Thus PAMmografie is relatively inexpensive, the measurements are painless, there is no contrast agent needed and it is with PAMmografie in principle possible to find also breast tumors in female breast tissue. Over time PAMmografie according Manohar, play an important role in the field of detection (screening), diagnosis, monitoring tumors during chemotherapy and in the detection of breast cancer in young women.

Despite the advances in research, Manohar guards against premature optimism. “Our method is relatively new, while MRI and mammography for example, for decades have had on development time. We need to do much research to further demonstrate the reliability of our technology. In the optimistic scenario, our method in about five to ten years deployed in niche areas. It will take longer for the regular method for screening and diagnosis can be deployed. “

Research

The research was conducted at the Department of Biomedical Photonic Imaging UT MIRA research. The investigation has been working closely with the Centre for Mammacare of the MST and the Laboratory of Pathology eastern Netherlands. Financial investigation is made possible by the National Enterprising Netherlands.

Authors of the article are Michelle Heijblom, Daniele Piras, Mariël Brinkhuis, Johan van Ham, Frank van den Engh, Margreet van der Schaaf, Joost Klaase, Ton van Leeuwen, Wiendelt Steenbergen and Manohar.


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