An analysis of published studies indicates that exclusive enteral nutrition (EEN)—when individuals receive only liquid nutrition—may be an effective treatment for children with Crohn’s disease. The findings are published in Alimentary Pharmacology & Therapeutics.
Crohn’s disease—a chronic inflammatory bowel disease—is often treated with steroids, which are associated with possible serious long-term side effects such as bone thinning, loss of muscle mass, weight gain, and an increased risk of infection. These effects are especially concerning in children.
Researchers who examined studies that compared EEN with steroids in children with active Crohn’s disease found that EEN was just as effective as steroids in controlling the inflammation of Cohn’s disease whether during the first attack or a relapse. In addition, healing of the intestine was over 4-times more likely in the EEN patients than in those given steroids.
“The most common question in a newly diagnosed patient is ‘what should I eat?’ with the idea that they are motivated to make the necessary changes to get control of their Crohn’s,” said Dr. Arun Swaminath, lead author of the analysis. “This would be an ideal time to discuss this treatment option, especially in pediatric populations, but it does require a motivated patient and a supportive team—typically composed of a dietician, nurse, and physician, and often, family/peer supporters—to make it all happen.”
Link to Study: http://onlinelibrary.wiley.com/doi/10.1111/apt.14253/full
Alimentary Pharmacology & Therapeutics is an international journal of gastroenterology and hepatology. The journal accepts original papers and systematic reviews concerned with clinical gastroenterology, hepatology and endoscopy. AP&T is particularly interested in therapies and diagnostics, including all aspects of translation from bench to bedside: identification of novel therapeutic targets, epidemiology, clinical trials, drug safety and meta-analyses.