Adenocarcinoma has been reported in four cases of gastric duplication cyst, but not in cysts that have a ciliated epithelium. Controversy exists concerning the embryological origin of these anomalies.
A research article to be published on January 7, 2011 in the World Journal of Gastroenterology addresses this question. The authors presented two cases of gastric ciliated duplication cyst with emphasis on immunophenotype and embryogenesis.
Two cases showed that the cysts are lined with a pseudostratified respiratory epithelium with ciliated cells, which express thyroid transcription factor-1 and surfactant. This suggests an origin from the respiratory diverticulum, which arises from the ventral foregut and could also explain why these cysts do or do not maintain their connection to the gastrointestinal tract.
Further research is required to explore the proposed mechanism. Better understanding of the embryogenesis of these lesions could lead to early diagnosis or even prevention.
Reference: Khoury T, Rivera L. Foregut duplication cysts: A report of two cases with emphasis on embryogenesis. World J Gastroenterol 2011; 17(1): 130-134 http://www.wjgnet.com/1007-9327/full/v17/i1/130.htm
Correspondence to: Thaer Khoury, MD, Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, United States. firstname.lastname@example.org
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About World Journal of Gastroenterology
World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2009 IF: 2.092. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.