The study was published this month in the Public Library of Science One (PLoS ONE).
The study analyzed inflammatory responses in rats fed different diets: control diets, a lard-based high-fat diet and a “cafeteria junk-food” diet consisting of nutrient-poor snacks such as salami, chocolate, cookies and chips.
“The diet that consisted of human junk food caused the most inflammation and dramatic metabolic changes,” said Liza Makowski, Ph.D., assistant professor of nutrition at UNC’s Gillings School of Global Public Health and the study’s senior author.
A junk-food diet contains many ingredients associated with increased risk for coronary artery disease, stroke and Type 2 diabetes, including saturated fat, trans-fats, sodium and cholesterol. The diet also is low in protective nutrients such as fiber.
While it has been known for some time that obesity can cause inflammation in fatty tissue, Makowski said, this study is one of the first to show that a junk-food diet may cause dramatic alterations in certain metabolites – molecular chemicals created when food is converted to energy.
These alterations may be responsible for obesity-induced inflammation and increased insulin resistance and could be a major contributing factor to metabolic syndrome, the cluster of factors that increase a person’s risk for coronary artery disease, stroke and Type 2 diabetes.
The junk-food diet used in the study may be superior to high-fat diets for modeling modern human obesity trends, including exposure to energy-dense and nutrient-poor diets, early and rapid obesity development, and elevated markers of metabolic syndrome and inflammation.
“Biomarkers revealed in our study could be useful in future studies,” said Makowski. “This needs to be replicated in human studies; it could be highly useful in future diabetes research.”
Study co-authors from UNC’s Gillings School of Global Public Health are Alex J. Freemerman, Ph.D., nutrition research associate; Pei-Fen Kuan, Ph.D., research assistant professor of biostatistics; Heather A. Brauer, Ph.D., postdoctoral research associate in epidemiology; and Melissa A. Troester, Ph.D., research assistant professor of epidemiology. Makowski, Kuan and Troester also are affiliated with the UNC Lineberger Comprehensive Cancer Center.
Other UNC-affiliated co-authors are Joseph A. Galanko, Ph.D., research assistant professor of medicine in the School of Medicine; Thomas M. O’Connell, Ph.D., of LipoScience Inc. and a former faculty member at the Eshelman School of Pharmacy; Brante P. Sampey, Ph.D., of Metabolon Inc. and a former postdoctoral fellow in nutrition; and Jimmy Zhang, an undergraduate enrolled for fall of 2012.
Other study co-authors are with the Sarah W. Stedman Nutrition and Metabolism Center at Duke University: Olga R. Ilkayeva, Ph.D., Michael J. Muehlbauer, Ph.D., Robert D. Stevens, Ph.D., and Christopher B. Newgard, Ph.D.
The study was funded by grants from the National Institutes of Health, Lineberger Comprehensive Cancer Center University Cancer Research Funds and a Freedom to Discover Award from Bristol Meyers Squibb.
Link to article online: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0038812
Gillings School of Global Public Health contact: Chris Perry, (919) 966-4555,