Double work and a high embarrassment factor can lead to the quality of life being affected more among women than men by irritable bowel syndrome (IBS), a very common gastrointestinal disease. Even with the same level of physical pain and other symptoms, women’s perceived quality of life is worse than the mens, according to new research.
Pediatric and Developmental Pathology – Sleep disordered breathing (SDB) can indicate reduction in airflow, habitual snoring, and obstructive sleep apnea. During pregnancy, SDB has been linked to complications such as gestational diabetes. Effects of SDB on the placenta are at the center of current research.
A group of researchers, led by Prof. MATOZAKI Takashi and Associate Prof. MURATA Yoji at the Kobe University Graduate School of Medicine Division of Molecular and Cellular Signaling, were the first to demonstrate the role of stomach cancer–associated protein tyrosine phosphatase (SAP)-1 in the pathogenesis and prevention of Crohn’s disease, ulcerative colitis, and other inflammatory bowel disorders.
In the United States, more than 1 million people suffer from inflammatory bowel disease (IBD), and its incidence around the world continues to rise. But treatment delivery options for patients remain limited: many people must rely on daily enemas, which can be uncomfortable, impractical and lead to side effects when medicine is absorbed by healthy tissue. Investigators from Brigham and Women’s Hospital (BWH) and collaborators from Massachusetts General Hospital (MGH) and MIT set out to find a better way to deliver medicine using a gel-like material created in the lab.
OTTAWA – The younger a person is when they immigrate to Canada, the higher their risk of developing inflammatory bowel disease (IBD), and its major subtypes Crohn’s disease and ulcerative colitis, according to a study by researchers at the Children’s Hospital of Eastern Ontario (CHEO), the Institute for Clinical Evaluative Sciences (ICES) and the University of Ottawa.
Image of a zebrafish in which the entire intestine is highlighted in red and the expression of the TNF molecule is highlighted in green. Duke researchers have discovered that a gene called uhrf1 acts like a kind of molecular handbrake on TNF, keeping it from setting off the series of pro-inflammatory and immune signals that drive inflammatory bowel diseases. Photo by Lindsay Marjoram