The Wellcome Trust-funded study confirms that the species has not yet adapted to humans and that monkeys are the main source of infection.
Malaria is a potentially deadly disease, killing over a million people each year. The disease is caused by parasites that are carried by infected mosquitoes and then injected into the bloodstream.
There are five species of malaria parasite that are known to cause disease in humans, of which Plasmodium knowlesi is the most recently identified. Previously thought to only infect monkeys, researchers have shown that human P. knowlesi infections are widely distributed in South-east Asia and that it is a significant cause of malaria in Malaysian Borneo. Until now, it was not clear whether the infection is transmitted from person to person or passed over from infected monkeys.
Researchers led by Professor Balbir Singh at the Malaria Research Centre, University Malaysia Sarawak, collaborating with Sarawak State Health Department, St George’s University of London and the London School of Hygiene and Tropical Medicine, examined blood samples from 108 wild macaques from different locations around the Sarawak division in Malaysian Borneo. Their results reveal that 78 per cent were infected with the P. knowlesi species of malaria parasite, and many were infected with one or more of four other species of monkey malaria parasites that have not yet been found in humans
By comparing the molecular identity of the parasites from monkeys and those isolated from patients with knowlesi malaria, the team were able to build a picture of the evolutionary history of the parasite and its preferred host. Their analysis reveals that transmission of the knowlesi species is more common amongst wild monkeys, than from monkeys to humans, and that monkeys remain the dominant host.
“Our findings strongly indicate that P. knowlesi is a zoonosis in this area, that is to say it is passed by mosquitoes from infected monkeys to humans, with monkeys acting as a reservoir host,” explains Professor Singh. “However, with deforestation threatening the monkeys’ habitat and increases in the human population, it’s easy to see how this species of malaria could switch to humans as the preferred host. This would also hamper current efforts aimed at eliminating malaria.”
Based on the molecular data, the researchers estimate that the knowlesi malaria species evolved from its ancestral species between 98 000 and 478 000 years ago. This predates human settlement in the area, meaning that monkeys are most likely to have been the initial host for the parasite when the species first emerged. This estimate also indicates that the species is as old as, or older than, the two most common human malaria parasites, P. falciparum and P. vivax.
The study is published today in the journal ‘PLoS Pathogens’.
Image: A long-tailed macaque (Macaca fascicularis). Credit: Anthony Sebastian.
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Notes to editors
Lee K-S et al. Plasmodium knowlesi: reservoir hosts and tracking the emergence in humans and macaques. PLoS Pathogens 2011 [epub ahead of print]
About the Wellcome Trust
The Wellcome Trust is a global charitable foundation dedicated to achieving extraordinary improvements in human and animal health. It supports the brightest minds in biomedical research and the medical humanities. The Trust’s breadth of support includes public engagement, education and the application of research to improve health. It is independent of both political and commercial interests.
About the London School of Hygiene & Tropical Medicine
The London School of Hygiene & Tropical Medicine (LSHTM) is a renowned research-led postgraduate medical school. Its mission is to contribute to the improvement of health worldwide through the pursuit of excellence in research, postgraduate teaching and advanced training in national and international public health and tropical medicine, and through informing policy and practice in these areas. Part of the University of London, the School is the largest institution of its kind in Europe with a remarkable depth and breadth of expertise encompassing many disciplines associated with public health.
About St George’s, University of London
St George’s, University of London (SGUL), established in 1733, is distinctive as the UK’s only independent medical and healthcare higher education institution. It benefits from strong links with the healthcare profession, including a shared site with St George’s Healthcare NHS Trust in Tooting, south-west London.
SGUL is dedicated to the education and training of doctors, nurses, midwives, physician’s assistants, paramedics, physiotherapists, radiographers, social workers, healthcare and biomedical scientists. It attracts around 6000 students, some of whom are taught in conjunction with Kingston University.
Research at SGUL has a UK and international focus and aims to improve prevention, diagnosis and treatment of disease in areas including infection and immunity, heart disease and stroke, and cell signalling. It also aims to enhance understanding of public health and epidemiology, clinical genetics, and social care sciences.