01:24pm Wednesday 13 December 2017

Organic medical imaging system to detect disease and track medication

Self assembling liposomes will be used in the biological medical scanners
The nano-transducers, made from fat found in the membrane of naturally occurring biological cells, could have a whole range of medical applications, including the potential to detect tumours earlier, monitoring electrical activity in the brain and tracking individual cells as they move around the human body.

The work is being led by Dr Melissa Mather, who said: “This research is very exciting as it paves the way for the development of tiny transducers that could be used in the human body without any risk of toxicity.

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“There is a growing need for sophisticated new imaging systems capable of studying cells and tissues in the body to support the development of emerging treatments that use human cells to treat conditions such as Parkinson’s disease and spinal injury, as well as chronic conditions such as diabetes or heart disease.

“The hope is that by introducing new healthy cells into the body they will help to restore the function of injured or diseased cells but to ensure these therapies have a positive effect, it is important that the location and behaviour of introduced cells are tracked once in the body. This is a challenging problem which current technologies are struggling to address.”

To support the work, Dr Mather, based in the University’s Institute of Biophysics, Imaging and Optical Sciences, has received a Career Acceleration Fellowship from the Engineering and Physical Sciences Research Council that will provide funding of more than £730,000 over the next five years.

Transducers are devices, traditionally made from single crystals such as quartz or ceramics, which can convert energy, such as electrical to mechanical. They are used as a method of testing in a wide range of applications, from locating cracks in metal structures to diagnosing diseases in humans.

Scientists have recently discovered that a wider range of materials can be used to make transducers than previously thought if they are miniaturised down to the nanoscale. In fact, it has been shown that the natural electrical activity of the body can be harnessed in biological membranes and converted into mechanical energy.

Dr Mather’s fellowship is centred on the design and manufacture of nano-sized transducers made from phospholipids, the main type of fat found in the membrane of biological cells. A key part of this will be forming the phospholipids into bubbles called liposomes to take advantage of their acoustic properties — a crucial element for using transducers as a means for testing. The research will look at different ways of increasing the power of the acoustic signal produced by modifying the composition, shape and size of the liposome.

These transducers will be used to develop a biological micro imaging system that will be able to produce diagnostic images of the body. By tagging the lipsomes with specific biological molecules, the transducers will also be able to target certain cell types, enabling them to act as beacons to locate cells in the body.

The final part of the research will focus on testing the capabilities of the new imaging system on tissue phantoms that mimic the human body, particularly in detecting tumours, monitoring electrical activity in the brain and tracking cells used in therapies. The aim is to have a working prototype of the system by 2016.

Dr Mather added: “The success of this work could hail a new type of organic medical imaging technology that could easily be used in a clinical setting at the point of care. This would have a significant impact in healthcare and enable new therapies to become available for clinical use and contribute to the health and wealth of society.”

Dr Mather is also a co-investigator at the EPSRC Centre for Innovative Manufacturing in Regenerative Medicine, a partnership between the universities of Loughborough, Nottingham and Keele.

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Notes to editors: The University of Nottingham, described by The Sunday Times University Guide 2011 as ‘the embodiment of the modern international university’, has award-winning campuses in the United Kingdom, China and Malaysia. It is ranked in the UK’s Top 10 and the World’s Top 75 universities by the Shanghai Jiao Tong (SJTU) and the QS World University Rankings. It was named ‘Europe’s greenest university’ in the UI GreenMetric World University Ranking, a league table of the world’s most environmentally-friendly higher education institutions, which ranked Nottingham second in the world overall.

The University is committed to providing a truly international education for its 40,000 students, producing world-leading research and benefiting the communities around its campuses in the UK and Asia.

More than 90 per cent of research at The University of Nottingham is of international quality, according to the most recent Research Assessment Exercise, with almost 60 per cent of all research defined as ‘world-leading’ or ‘internationally excellent’. Research Fortnight analysis of RAE 2008 ranked the University 7th in the UK by research power. The University’s vision is to be recognised around the world for its signature contributions, especially in global food security, energy & sustainability, and health.

More news from the University at: www.nottingham.ac.uk/news

Story credits

More information is available from Dr Melissa Mather on +44 (0)115 951 5337, melissa.mather@nottingham.ac.uk

Emma Thorne

Emma Thorne – Media Relations Manager

Email: emma.thorne@nottingham.ac.uk Phone: +44 (0)115 951 5793 Location: King’s Meadow Campus


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