This breakthrough in the understanding of the mechanisms underlying allergy could have important applications in the treatment of asthma and other allergic diseases such as eczema and allergic rhinitis. Co-directed by CNRS researcher Corinne Cayrol and INSERM senior researcher Jean-Philippe Girard, this work is published in PNAS on 13 October 2014.
The central domain of IL-33 is cleaved by mast cell proteases for potent activation of group 2 innate lymphoid cells. E. Lefrançais, A. Duval, E. Mirey, S. Roga, E. Espinosa, C. Cayrol and J-P. Girard. PNAS, 2014, in press.