Today, about half of the drugs on the market were discovered by screening collections of small molecules made by bacteria, fungi, snails, leeches and other such species.
Although the pharmaceutical industry has made serious efforts to get away from relying on the natural world by attempting to create rationally designed drugs using synthetic compounds, nature-derived drugs still constitute a substantial percentage (26%) of recently approved drugs.
Nature-derived drugs not in every species
The conventional view about nature-derived drugs is that as every nature species produces biologically active molecules, one can find drugs from almost any major block of species groups if one looks and searches them hard enough.
This view has been proven wrong in a first-ever comprehensive study of the species origins of nature-derive drugs conducted by researchers from the National University of Singapore (NUS) and Tsinghua University. Published in Proceedings of the National Academy of Sciences of the United States of America in July 2011, the research showed that drug producing species are concentrated and clustered in a limited number of families.
Data analysed by the research team showed that out of 886 nature-derived drugs discovered in the last 50 years (1961 to 2010), 88% or 783 were from previously known drug producing families. A further 41 were from near neighbours of known productive families. Only 62 came from ‘dark horses’ that were completely outside of the known clusters.
Lead researcher Professor Chen Yu Zong from the Department of Pharmacy at NUS, said, “In each kingdom of life, the drug-producing families are strongly clustered. Only a limited number of molecular scaffolds are privileged drug-like structure made by specific metabolic genes in certain species families. Some families with lots of bioactive compounds have never produced a drug because their metabolic genes are not capable of producing privileged drug-like structures, even though they can produce bioactive structures. ”
Focus on family members
The findings from this research can now point us to the direction on where to concentrate on the search of new drugs, and that is from pre-existing drug-productive families.
In explaining this rationale, Prof Chen said, “We have identified and highlighted a number of families that have not produced an approved drug but are likely in the drug-producing clusters and potentially produce future approved drugs. Just like by knowing the clustered distribution patterns of oil fields, one knows where to place their bets on the next oil field based on existing findings. For instance, if one finds the first oil-producing well somewhere in the South China seas, by knowing that oil fields tend to be clustered, there is a higher chance in finding the next oil fields by a search of the surrounding areas.”
By focusing on pre-existing drug-productive families, resources can be concentrated on manipulating and expanding the families for producing new, as well as existing drugs. In addition, these pre-existing drug-productive families can be studied on why they produce privileged drug-like structures, and the knowledge can be used for designing new and novel drugs.