12:47pm Thursday 21 September 2017

Living cells, environmental contaminants and chemicals

 

Illustration photo: foodDuale studied the effects of three substances; acrylamide in food, OMC used in sunscreen and cisplatin which is used to treat cancer.

Duale has shown the effects of these substances on cell cultures and human blood, which can include genetic mutations and DNA damage.

Results

Acrylamide, which forms in different foods during the cooking process, is carcinogenic in laboratory animals and probably also in humans. However, the study shows that humans probably have different sensitivity to acrylamide and that this is related to the combination of different gene variants in humans. The study contributes to increased knowledge about how the relationship between the intake of acrylamide and cancer risk can more easily be discovered.

Octyl methoxycinnamate (OMC) is a substance used in many types of sunscreen and to protect against sunlight. However, the substance does not always have a protective effect when it is exposed to ultraviolet rays. Duale’s study provides improved knowledge about how the effect of OMC can be tested at the cellular level.

Cisplatin is used in cancer treatment and has proved to be particularly effective against certain cancers, especially in the treatment of testicular cancer. The researcher’s study confirms that cisplatin does not give such a positive effect on cancer cells in organs other than the testicles.

The doctoral work was conducted in the Department of Chemical Toxicology at the NIPH, where Duale is employed as a researcher.

Doctoral Thesis

Causes and consequences of cellular response to toxicants – Potential applications of functional genomics in toxicology


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