08:42pm Wednesday 23 October 2019

Vitamin supplementation could have a significant impact on maternal and fetal health, says new review

The review was led by researchers at King’s College London and looks at existing evidence and current guidelines on vitamin supplementation in pregnancy.

Vitamins are essential for normal cell function, growth and development. During pregnancy there is an increased demand for vitamins such as folic acid, yet intake among women of reproductive age in the UK is reported as low, says the review.

Certain vitamins if taken around the time of conception and in early pregnancy can reduce the likelihood of neural tube defects and other fetal anomalies.
Furthermore, the review states that there is debate surrounding the role of supplementary vitamins in the reduction of certain diseases of pregnancy, such as pre-eclampsia, preterm birth and small-for-gestational-age infants.

The review states that free provision of vitamins to all pregnant women should be considered and the benefits would outweigh the costs.

Folic acid supplementation (400 micrograms/day) is recommended preconceptually and during the first trimester of pregnancy. It has a strong protective effect against neural tube defects, however, a recent systematic review estimated that only 21-48% of mothers take folic acid supplements around the time of conception, say the authors.

Fortification of flour with folic acid is explored in the review. The authors state that mandatory fortification should be explored and this would assist in reducing the incidence of neural tube and other congenital defects.

During pregnancy, vitamin A and B supplementation is not recommended, however, a multivitamin with low doses of vitamins C and E is recommended, says the review. Vitamin C has important roles in collagen synthesis, wound healing, prevention of anaemia and as an antioxidant.

Vitamin D supplementation is recommended in women at risk of deficiency. It is naturally found from exposure of skin to sunlight. However deficiency is often found in women of South Asian, African, Caribbean or Middle Eastern ethnic origin, women who have limited exposure to sunlight and women with a pre-pregnancy BMI of more than 30.

Vitamin D deficiency has been associated with infantile rickets (with severe deficiency), while supplementation of the vitamin has been linked with reduced childhood wheezing and reduced type I diabetes in children, says the review.

The authors recommend that pregnant women at risk of vitamin D deficiency, in particular obese women, should be identified and encouraged to take supplements of 10 micrograms/day.

Dr Lucy Chappell, Senior Lecturer in Maternal and Fetal Medicine at King’s College London, and co-author of the review said:

“Vitamins are an essential part of a healthy diet. A varied package of interventions may be needed to increase uptake, particularly for those groups with the
lowest use but there are considerable difficulties with any approach, particularly given the significant unplanned pregnancy rate in the UK.

“However, if any woman is concerned about vitamin deficiency, or would like advice on which supplements might benefit them, they should contact their GP.

“Further research is needed to look at potential harms of supplementation, benefits and optimal dosages.”

TOG’s Editor –in-Chief, Jason Waugh said:

“It is important for all women to eat a healthy diet, however, for women trying for a baby and during early pregnancy, some supplementation can be beneficial.

“Folic acid supplementation is recommended and vitamin D is now recommended by the Chief Medical Officers in the UK for all pregnant women to ensure the mother’s requirements are met. It is important that women are aware of their diet and eat a range of foods alongside keeping active and leading a healthy lifestyle.”


To speak to the author please contact Emma Reynolds, Press Officer, King’s College London on 020 7848 4334 or emma.reynolds@kcl.ac.uk

For more information about TOG please contact Naomi Weston on 020 7772 6357 or nweston@rcog.org.uk 


The Obstetrician & Gynaecologist (TOG) is published quarterly and is the Royal College of Obstetricians and Gynaecologists’ (RCOG) medical journal for continuing professional development. TOG is an editorially independent, peer reviewed journal aimed at providing health professions with updated information about scientific, medical and clinical developments in the specialty of obstetrics and gynaecology.


Duckworth S, Mistry HD, Chappell LC. Vitamin supplementation in pregnancy. The Obstetrician & Gynaecologist 2012;14:175–178.

Royal College of Obstetricians and Gynaecologists

27 Sussex Place, Regent’s Park, London NW1 4RG, UK | Tel: +44 (0)20 7772 6200 / Fax: +44 (0)20 7723 0575

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