09:29am Tuesday 24 October 2017

Study Is First to Show Transgenerational Effect of Antibiotics

Photo of the pseudoscorpion Cordylochernes scorpioides.Male reproductive function in Cordylochernes scorpioides is affected by tetracycline.

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In a paper published in Nature‘s open access journal Scientific Reports, researchers at the University of Nevada, Reno, report that male pseudoscorpions treated with the antibiotic tetracycline suffer significantly reduced sperm viability and pass this toxic effect on to their untreated sons. They suggest a similar effect could occur in humans and other species.

A pseudoscorpion, whose scientific name is Cordylochernes scorpioides, is a tiny eight-legged arachnid that has the false appearance of a scorpion. Its sperm packets are transferred externally, making it possible for investigators to simply collect them and assess the quality and quantity of sperm.

“This is the first research to show a transgenerational effect of antibiotics,” said David Zeh, lead author and chair of UNR’s department of biology in the College of Science. “Tetracycline has a significant detrimental effect on male reproductive function and sperm viability of pseudoscorpions–reducing viability by up to 25 percent–and now we know that effect is passed on to the next generation. We didn’t see the effect in subsequent generations.”

The research involved a three-generation study of the pseudoscorpion. To control for genetic influences, in the first generation, brothers and sisters from each of 21 broods were treated with weekly doses of tetracycline, an antibiotic commonly used in animal production and generally used for treatment of infections in humans. The broods were treated from birth to adulthood or were reared as untreated controls. Subsequent generations were not treated with tetracycline. The antibiotic had no effect on male or female body size, sperm number or female reproduction, they found.

“Tetracycline, one of the most widely used antibiotics, has previously been shown to have negative effects on male reproduction in vertebrates, including humans,” said George Gilchrist, program director in the Division of Environmental Biology at the National Science Foundation, which funded the study.

“This study confirms that effect in these unusual invertebrates, but also demonstrates a toxic effect across generations. It is of broad importance because of the potential for cross-generational effects on the fertility of food animals and humans, which has never before been examined.”


Media Contacts
Bobbie Mixon, NSF (703) 292-8485 bmixon@nsf.gov
Mike Wolterbeek, University of Nevada, Reno (775) 784-4547 mwolterbeek@unr.edu

Program Contacts
George W. Gilchrist, NSF (703) 292-7138 ggilchri@nsf.gov

Jeanne Zeh, University of Nevada, Reno (775) 784-1648 jaz@unr.edu
David W. Zeh, University of Nevada, Reno (775) 784-1648 zehd@unr.edu

The National Science Foundation (NSF) is an independent federal agency that supports fundamental research and education across all fields of science and engineering. In fiscal year (FY) 2012, its budget is $7.0 billion. NSF funds reach all 50 states through grants to nearly 2,000 colleges, universities and other institutions. Each year, NSF receives over 50,000 competitive requests for funding, and makes about 11,000 new funding awards. NSF also awards nearly $420 million in professional and service contracts yearly.

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