08:29am Tuesday 15 October 2019

Single-cell parasites co-opt “ready-made” genes from host: uOttawa research

Part of a group of parasitic microbes called microsporidia, Encephalitozoon hellem and Encephalitozoon romaleae are related to fungi and are commonly found in the intestines of vertebrates. In humans, they are associated with people with immune deficiencies.

The research team identified six genes in these parasites that were not found in any other microsporidian. Rather than slowly inheriting individual genes, E. hellem and E. romaleae have acquired a suite of genes from their hosts that produce folate, a form of folic acid that helps cell division and growth.

“The discovery of these genes underpins the surprising capacity of even the most reduced parasites genomes to rapidly improve their metabolism by acquiring several genes that build-up new pathways, perhaps allowing them to quickly adapt to new hosts.” says Nicolas Corradi, Assistant Professor, Department of Biology, University of Ottawa.

Details are published this week in the online journal PNAS Early Edition.

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