This mutation affects the neuronal nicotinic receptor, disrupting its function and resulting in partial inactivation of the “reward circuit”. Carriers of this mutation therefore have to increase their consumption to feel the effects of tobacco. These results, published online on December 3, 2013 in Molecular Psychiatry, pave the way for the development of new smoking cessation treatments that target carriers of this mutation.
Nicotine consumption is regulated by a human polymorphism in dopamine neurons, Molecular Psychiatry, December 3, 2013.
C Morel (1,9), L Fattore (2,9), S Pons (3), YA Hay (4), F Marti (1), B Lambolez (4), M De Biasi (5), M Lathrop (6,7), W Fratta (8), U Maskos (3,9) and P Faure (1,9)
(1) Neurobiology of Adaptive Processes, CNRS UMR 7102, Neurophysiology and Behavior team (NPC), Pierre and Marie Curie University, Paris, France
(2) CNR Neuroscience Institute, Cagliari, National Research Council, Italy, Cittadella Universitaria, Monserrato, Italy
(3) Institut Pasteur, Integrative Neurobiology of Cholinergic Systems Candidate Unit, CNRS UMR 3571, Paris, France
(4) Pierre and Marie Curie University, CNRS UMR 7102, Neurobiology of Adaptive Processes, Cortical network and Neurovascular Coupling team, Paris, France
(5) Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
(6) McGill University and Genome Quebec Innovation Centre, Montréal, QC, Canada
(7) Fondation Jean Dausset-CEPH, Paris, France
(8) Department of Biomedical Sciences, University of Cagliari Cittadella Universitaria, Monserrato, Italy
(9) These authors contributed equally to this work.