Researchers from the Laboratoire Pathologie et Virologie Moléculaire (CNRS/Inserm/Université Paris Diderot)2, in collaboration with researchers from CEA3 and a US laboratory4, have identified an interaction between two proteins that is essential for the integration of a transposable element into a specific area of the yeast genome. These results, published on 1 May 2015 in the journal Science, emphasize the role of these mobile DNA sequences in the evolution and adaptation of organisms, and their potential value for gene therapy.
1 A transposable element is a DNA sequence capable of moving independently in a genome. Such mobile sequences are present in all living organisms and are considered powerful drivers of evolution and biodiversity.
2 Partner laboratory of the Conservatoire national des arts et métiers (CNAM).
3 From the Institut de biologie intégrative de la cellule (CNRS/CEA/Université Paris-Sud).
4 Department of Genetics, Cell Biology & Development and Center for Genome Engineering (University of Minnesota).
An RNA polymerase III subunit determines sites of retrotransposon integration, A. Bridier-Nahmias, A. Tchalikian-Cosson, J.A. Baller, R. Menouni, H. Fayol, A. Flores, A. Saïb, M. Werner, D.F. Voytas & P. Lesage, Science, 1 May 2015.