10:57am Friday 20 October 2017

How does a mobile DNA sequence find its target ?

Researchers from the Laboratoire Pathologie et Virologie Moléculaire (CNRS/Inserm/Université Paris Diderot)2, in collaboration with researchers from CEA3 and a US laboratory4, have identified an interaction between two proteins that is essential for the integration of a transposable element into a specific area of the yeast genome. These results, published on 1 May 2015 in the journal Science, emphasize the role of these mobile DNA sequences in the evolution and adaptation of organisms, and their potential value for gene therapy.

To dowload the press release: Press release_Retrotransposon

 

Notes:

1 A transposable element is a DNA sequence capable of moving independently in a genome. Such mobile sequences are present in all living organisms and are considered powerful drivers of evolution and biodiversity.

2 Partner laboratory of the Conservatoire national des arts et métiers (CNAM).

3 From the Institut de biologie intégrative de la cellule (CNRS/CEA/Université Paris-Sud).

4 Department of Genetics, Cell Biology & Development and Center for Genome Engineering (University of Minnesota).

References:

An RNA polymerase III subunit determines sites of retrotransposon integration, A. Bridier-Nahmias, A. Tchalikian-Cosson, J.A. Baller, R. Menouni, H. Fayol, A. Flores, A. Saïb, M. Werner, D.F. Voytas & P. Lesage, Science, 1 May 2015.

Contact information:

CNRS Researcher l Pascale Lesage l T 0033 (0)1 53 72 40 59 l pascale.lesage@inserm.fr

CNRS Press officer l Lucie Debroux l T 0033 (0)1 44 96 43 09 l lucie.debroux@cnrs-dir.fr


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