Moore, Dartmouth Medical School’s Frank Lane Research Scholar in Computational Genetics and director of bioinformatics, joined six fellow geneticists in writing opinions in a “Viewpoint” article for the June 2010 edition of the journal, on where and how to find missing genetic factors that trigger the diseases.
“The time is now to philosophically and analytically retool for a complex genetic architecture or we will continue to underdeliver on the promises of human genetics,” Moore, a DMS professor of genetics and of community and family medicine, writes in his essay. “Indeed, life, and thus genetics, is complicated and some will soon ask, as seismologists have [about earthquakes], whether we are trying to predict the unpredictable.”
Moore and his colleagues explain how various factors, including structural variants, epigenetic regulation, and genetic interactions, could contribute to common human disease.
“The field of genetics has been dominated by simple approaches to the problem and have not achieved much success,” Moore says. “My research program directly confronts this complexity by developing powerful computational algorithms and software for looking t interactions between multiple genetic and environmental risk factors.”