The 10 Best CBD Oil Brands To Buy in 2021

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Medically reviewed by Kathy Shattler, MS, RDN

Royal Spectrum CBD Oil

Royal CBD

  • Premium, CO2 extracted hemp CBD 
  • Full-spectrum CBD 
  • Precise dosing with the included dropper

20% Off Coupon: HC20

CBDistillery

CBDistillery

  • Affordable prices
  • Wide variety of CBD products 
  • Free shipping on orders over $75

15% Off Coupon: HEALTHCANAL

Spruce Max Potency CBD Oil

Spruce CBD

  • Lab-grade strength
  • Heirloom strain 
  • Independent lab testing

Free Shipping and 15% Off Coupon: HEALTHCANAL

People are always searching for the next secret to improved health and wellness. In recent years, CBD oil has been a rising trend. This all-natural supplement has touted benefits ranging from pain and anxiety relief to reductions in seizure activity. Not only does CBD offer a wide array of potential health benefits, but it comes in a variety of different forms. 

When shopping for CBD, you’ll find dozens of brands on the market, so how do you make the right choice? The best CBD oil is made from high-quality hemp and carefully extracted and thoroughly tested for purity and potency. Read on to learn about the benefits of CBD, how to shop for it, and which brands are best. 

Best CBD Oils On The Market in (October. 2021)

What Is CBD Oil?

Cannabidiol, often shortened to CBD[1], is a naturally occurring chemical found in cannabis. Both Cannabis sativa (hemp) and Cannabis indica (marijuana) contain CBD but in differing concentrations. While marijuana contains high concentrations of another cannabinoid compound, tetrahydrocannabinol (THC), the hemp plant is rich in cannabidiol. CBD oil is simply an extract from one of these two plants. 

CBD oil is generally made from hemp extract combined with some kind of carrier oil like coconut oil or hemp seed oil. Depending on how the CBD is extracted, CBD oil products are labeled either full-spectrum or broad-spectrum. Full-spectrum oil contains the full array of cannabinoids[2] and other naturally occurring plant compounds from the cannabis plant. Broad-spectrum CBD contains all but the THC and CBD isolates have been processed to remove all additional compounds, leaving only the cannabidiol. 

The Line Up At A Glance

Royal Spectrum CBD Oil

Editor’s choice

Royal CBD

  • Premium, CO2 extracted hemp CBD 
  • Full-spectrum CBD 
  • Precise dosing with the included dropper

20% Off Coupon: HC20

CBDistillery

Most Affordable

CBDistillery

  • Affordable prices
  • Wide variety of CBD products 
  • Free shipping on orders over $75

15% Off Coupon: HEALTHCANAL

Spruce Max Potency CBD Oil

Best Lab Grade

Spruce CBD

  • Lab-grade strength
  • Heirloom strain 
  • Independent lab testing

Free Shipping and 15% Off Coupon: HEALTHCANAL

CBDfx CBD + CBN Oil Tincture

Most Sustainable

CBDfx

  • Wide variety of CBD oil products 
  • Organically grown, non-GMO hemp extracts
  • Free shipping on orders over $35

25% Off Coupon: HEALTHCANAL

CBDPure Hemp Oil 600mg

Most Natural

CBDPure

  • Certified non-GMO organic hemp extract
  • Backed by a 90-day money-back guarantee
  • Full-spectrum CBD oils

Free Shipping and 15% Off Coupon: HEALTHCANAL

Joy Organics CBD Oil

Best Broad Spectrum

Joy Organics

  • All products are USDA certified organic
  • Flavored and unflavored broad-spectrum CBD oil
  • Free carbon neutral shipping on all orders

Check Price

20% Off Coupon: HEALTHCANAL

NuLeaf Naturals Tinctures

Most Consistent

Nuleaf Naturals

  • Supercritical CO2 extracted hemp extract
  • Third-party lab testing 
  • All CBD oils contain 60 mg/ml CBD

Check Price

20% Off Coupon: HEALTHCANAL

Lazarus Naturals

Best Flavor

Lazarus Naturals

  • Wide range of flavor options
  • Standard and high potency CBD oils
  • Free shipping on orders over $25

10% Off Coupon: HEALTHCANAL10

CBDEssence

Best Small Batch

CBD Essence

  • Dropper or sprayer application
  • Small batch company
  • Produced within 24 hours of shipment

20% Off Coupon: Health20

Hemp Bombs CBD Oil

Best CBD Isolate

Hemp Bombs

  • Six flavors for each CBD oil tincture 
  • Premium hemp CBD extract
  • Subscribe and save 20% on every order

20% Off Coupon: HEALTHCANAL

Top 10 Best CBD Oil Brand Reviews  

Royal CBD

Royal Spectrum CBD Oil

20% Off Coupon: HC20

See Royal CBD Reviews

Made with 100% organic ingredients and lab-tested for quality and safety, Royal CBD is a top-of-the-line CBD brand. If you want the best of the best, go with Royal CBD.

  • Premium, CO2 extracted hemp CBD 
  • Full-spectrum CBD tinctures
  • Precise dosing with the included dropper
  • A limited selection of CBD oils
  • Somewhat pricey

When buying CBD oil online, it’s important to find a reputable company that offers safe, effective, high-quality products. Royal CBD sources top-shelf hemp and uses supercritical CO2 extraction to create high-quality CBD oil. Their tinctures range from 250 mg to 2,500 mg CBD per bottle and dosing is made easy with the included dropper which precisely measures 1ml of liquid. All products are made with 100% organic ingredients and rigorously tested by third-party labs. We also love that this brand offers free shipping on all orders and their oils come in several appealing flavors, including vanilla, berry, and natural mint flavor.

CBDistillery

CBDistillery

15% Off Coupon: HEALTHCANAL

See CBDistillery Reviews

You don’t necessarily need to spend a fortune to get decent quality CBD oil. CBDistillery offers a wide range of products at affordable prices.

  • Affordable prices
  • Wide variety of CBD products 
  • Free shipping on orders over $75
  • Limited flavor options

Choose from a wide variety of full-spectrum and broad-spectrum CBD products, all at surprisingly affordable price points. CBDistillery offers CBD oils ranging from 500 mg to 5,000 mg CBD per 30ml bottle for human use and several concentrations for pets. This CBD company uses non-GMO industrial hemp grown in the USA using all-natural farming practices. Their hemp is U.S. Hemp Authority-certified and tested by third-party labs to ensure the highest quality. Every purchase comes with a 60-day money-back guarantee, and you can save 20% with a recurring subscription (AND receive free shipping on your order).

Spruce CBD

Spruce Max Potency CBD Oil

Free Shipping and 15% Off Coupon: HEALTHCANAL

See Spruce CBD Reviews

When it comes to pure, high-quality CBD, you can’t do better than Spruce CBD. Made from an heirloom strain of hemp; this CBD brand offers high potency, lab-grade products.

  • Highly potent lab-grade products
  • Made with an heirloom strain of hemp
  • Independent third-party testing
  • Limited product selection
  • Unflavored
  • Fairly expensiv

Founded in 2018, Spruce CBD has gained a reputation for providing high-quality CBD products. This brand uses lab-grade, full-spectrum CBD to create highly concentrated products that contain the full array of natural cannabinoids, terpenes, essential oils, and flavonoids the hemp plant has to offer. All products are pure and natural, completely free from artificial flavors and sweeteners. Every product is thoroughly tested by independent third-party labs to verify its purity and potency. Choose from 750 mg or 2,400 mg CBD oil as well as CBD creams, salves, and lotions. Subscribe to save 15% and receive free shipping on your recurring order.

CBDfx

CBDfx CBD + CBN Oil Tincture

25% Off Coupon: HEALTHCANAL

See CBDfx Reviews

If sustainability is a concern for you, you’ll love CBDfx. This CBD company offers a variety of CBD tinctures that are 100% vegan, non-GMO, and all-natural.

  • Wide variety of full- and broad-spectrum CBD oil
  • Organically grown, non-GMO hemp extracts
  • Free shipping on orders over $35
  • Limited flavor options

Founded in 2014, CBDfx has always been dedicated to producing the best, safest, and most effective CBD products on the market. Located in the San Fernando Valley, CBDfx has grown into the second-largest privately held CBD company in the world, offering full-spectrum, broad-spectrum, and CBD isolate. All of their products are expertly selected, organically grown, pesticide-free, and non-GMO. You can find a CBD oil tincture ranging from 500 mg to 6,000 mg, including sets designed to deliver specific benefits such as calming or sleep. All products are lab-tested, cruelty-free, and made in the USA. 

CBDPure

CBDPure Hemp Oil 600mg

Free Shipping and 15% Off Coupon: HEALTHCANAL

See CBDPure Reviews

Maximize the wellness benefits of your CBD products by choosing high-quality, pure CBD oil. CBDPure is true to its name, offering only organic, all-natural CBD oil products.

  • Certified non-GMO organic hemp extract
  • Backed by a 90-day money-back guarantee
  • Full-spectrum CBD oil
  • Limited product selection
  • No options for flavors

While their product selection may be more limited than some CBD oil companies, CBDPure offers high-quality products that make it worth your while. Their CBD oil is made from certified non-GMO organic hemp grown in Colorado and Washington, guaranteed to be free from contaminants and artificial additives. Choose from three CBD oil concentrations (300 mg, 600 mg, or 1,000 mg CBD per bottle) and enjoy the benefits of full-spectrum, organic hemp extracts. Not only do CBDPure products offer exceptional quality, but they offer great value as well. Affordably priced and backed by a 90-day money-back guarantee, these CBD products are a great buy.

Joy Organics

Joy Organics CBD Oil

Check Price

20% Off Coupon: HEALTHCANAL

See Joy Organics Reviews

Easily one of the most trustworthy CBD companies out there, Joy Organics is our top pick for broad-spectrum CBD oil. As the name suggests, all products are USDA-certified organic.

  • All products are USDA certified organic
  • Flavored and unflavored broad-spectrum CBD oil
  • Free carbon neutral shipping on all orders
  • Somewhat pricey
  • No international shipping

While Joy Organics does offer full-spectrum CBD, they have a larger selection of broad-spectrum CBD oil. With prices starting under $50, this brand is surprisingly affordable and offers an array of benefits other CBD brands don’t. Not only do they offer a number of different flavors like Tranquil Mint, Fresh Lime, and Orange Bliss, but they offer low dosages as well. Joy Organics CBD products range from 15mg CBD per serving up to 75 mg CBD per serving. In addition to being THC-free, these broad-spectrum products are cruelty-free and backed by a 90-day satisfaction guarantee. Joy Organics also utilizes carbon-neutral shipping.

Nuleaf Naturals

NuLeaf Naturals Tinctures

Check Price

20% Off Coupon: HEALTHCANAL

See Nuleaf Naturals Reviews

If you’re new to CBD, you may be nervous about the hassle of determining the proper dose. With Nuleaf Naturals, all their CBD tinctures contain the same concentration of CBD per bottle to make things extra easy.

  • Supercritical CO2 extracted hemp extract
  • Third-party lab testing 
  • All CBD oils contain 60 mg/ml CBD
  • Limited product selection
  • No flavored options

While there are no standard dosing recommendations for CBD, the best CBD companies do what they can to make the process easier. Nuleaf Naturals is unique in that all of their CBD oil tinctures contain the same concentration of CBD per bottle – 60 mg/ml. Not only is Nuleaf Naturals incredibly consistent, but their products offer excellent quality as well. Using proprietary genetics, this brand has created their own whole plant CBD extra that is highly concentrated with CBD and secondary cannabinoids like CBN, CBG, and CBC. They use supercritical CO2 extract to remove the CBD from the cannabis plant, ensuring optimal purity and potency which is verified through third-party lab testing.

Lazarus Naturals

Lazarus Naturals

10% Off Coupon: HEALTHCANAL10

See Lazarus Naturals Reviews

Even the best CBD oils have an earthy flavor some people find unpleasant but Lazarus Naturals offers a wide range of flavored CBD oils that make the experience of taking CBD more pleasant.

  • Wide range of flavor options
  • Standard and high potency CBD oils
  • Free shipping on orders over $25
  • Some flavors may be overwhelming

If you generally find the taste of a CBD oil tincture unpleasant, you may want to try flavored CBD oil from Lazarus Naturals. Though still made with the standard carrier oil (coconut MCT oil), Lazarus Naturals CBD comes in a variety of flavors like Mint Chocolate, Chai Tea Latte, Apple Cider, and more. You get the same benefits from a premium CBD product without the earthy taste. Lazarus Naturals offers both standard and high potency CBD oil ranging from 20 mg CBD per milliliter up to 50mg CBD per milliliter. Choose from full-spectrum CBD or broad-spectrum oil and shop their selection of pure CBD concentrates and topicals.

CBD Essence

CBDEssence

20% Off Coupon: Health20

See CBD Essence Reviews

If you’re going to buy CBD oil, you want to know it’s going to work. CBD Essence is a small batch company that produces everything within 24 hours of shipment, so you know it’s fresh.

  • Dropper or sprayer application
  • Small batch company
  • Produced within 24 hours of shipment
  • Shipping only to theUS and Canada

Founded in 2014, CBD Essence is a small batch CBD company that offers premium quality products with a 60-day satisfaction guarantee. Older than many CBD oil brands, CBD Essence has a trusted reputation in the industry and offers a wide range of products, including CBD gummies, tinctures, topicals, vapes, and more. When it comes to their oils, CBD Essence offers only full-spectrum formulas in concentrations ranging from 300mg to 2,400mg. Their products utilize a sublingual formula for fast assimilation,and everything is guaranteed to be produced within 24 hours of shipment. Choose from a dropper or sprayer in your bottle and select from a variety of flavors including cinnamon, grape, mango, and spearmint.

Hemp Bombs

Hemp Bombs CBD Oil

20% Off Coupon: HEALTHCANAL

See Hemp Bombs Reviews

If you want to gain the maximum benefit from your CBD oil tincture, go with CBD isolate from Hemp Bombs. This pure CBD offers unbeatable quality and comes in six tasty flavors.

  • Six flavors for each CBD oil tincture 
  • Premium hemp cannabidiol extract
  • Subscribe and save 20% on every order
  • Limited info about the company available

Hemp Bombs uses the highest quality raw CBD and other hand-selected ingredients to make all of their products. Whether you’re going with pure CBD isolate or a full-spectrum CBD product, you can count on Hemp Bombs to deliver on quality. This brand uses pure CBD extract sourced from industrial hemp plants grown on American farms, all of which come with a certificate of analysis. Not only does this company use premium-quality ingredients, but everything is verified for purity and potency through third-party testing with the results published on their site. Choose from a variety of CBD products including oils, CBD gummies, CBD isolates, and more. Oils are available in concentrations ranging from 300 mg CBD per bottle to 5,000 mg CBD per bottle.

Benefits Of CBD Oils

Unlike THC, another cannabinoid compound derived from the cannabis plant, CBD is not psychoactive. That being said, it does have the potential to offer a variety of health benefits[3]

Some of the potential benefits of CBD include: 

  • Anxiety reduction
  • Lowering blood pressure
  • Pain relief
  • Relief from insomnia
  • Reduction in seizure activity 
  • Addiction support
  • Anti-inflammatory benefits

While there is anecdotal evidence for a variety of benefits, the three most tested health and wellness benefits for CBD are related to pain relief, anxiety, and seizure reduction. Read on to learn more about the scientifically proven benefits of CBD. 

Pain Relief

The use of cannabis for pain relief dates back as far as 2900 B.C., but human trials are still somewhat limited. Scientists have recently discovered that the pain-relieving effects of CBD are related to its impact on the endocannabinoid system[4] (ECS) found in all mammals. By impacting endocannabinoid receptor activity, reducing inflammation, and interacting with neurotransmitters, CBD may help reduce chronic pain[5].

In a 2012 animal study[6], rats treated with an oral dose and spinal injection of CBD experienced a reduction in inflammation and neuropathic pain. Human studies are still limited, but several countries have approved an oral spray called Sativex which contains both CBD and THC as a treatment for pain related to multiple sclerosis (MS). A small study[7] of 47 individuals found that Sativex improved pain, walking, and muscle spasms in patients with MS.

Anxiety 

Anxiety and depression are two of the most common mental health disorders in the United States and, according to the World Health Organization[8] (WHO), are among the largest contributors to disability worldwide. Some evidence suggests that CBD can help with both. 

A 2015 review[9] published in Neurotherapeutics comments that strong preclinical evidence exists to support CBD as a treatment for generalized anxiety disorder as well as other anxiety disorders, including obsessive-compulsive disorder and post-traumatic stress disorder (PTSD). Though there are only a few human trials, the results are promising. 

A Brazilian study[10] published in 2019 found that a 300mg dose of CBD significantly reduced test anxiety. Several animal studies[11] have also shown that CBD has antidepressant-like effects. 

Seizures

While studies for most applications of CBD are limited, the greatest amount of evidence exists in support of its anti-seizure properties. In fact, the only FDA-approved form of CBD is a drug called Epidiolex, which is used to treat certain forms of epilepsy. 

While the exact mechanism responsible for CBD’s anticonvulsant benefits is unknown, a 2014 article[12] published in the journal Epilepsia suggests it may be related to CBD’s effect on various receptors and neurotransmitters, including GPR55 and 5-HT1a. In a 2015 study[13], patients with Lennox-Gastaut syndrome experienced a reduction in seizures after 12 weeks of regular treatment with Epidiolex, most with minor side effects including decreased appetite, fever, and diarrhea. 

How To Choose The Best CBD Oils?

Cannabidiol is a natural plant compound, but not all CBD oil products are the same. The best CBD oil is made with high-quality hemp extract without any artificial additives and processed in a way that guarantees the safety and efficacy of the product. 

Tips for Buying CBD

Before buying CBD, there are several questions you need to ask yourself. First and foremost, what benefit do you hope to gain from taking CBD? This will help you determine whether you should go for broad-spectrum or full-spectrum CBD oil and it may impact your decision on concentration. Think about whether you prefer to take oil or if you’d be more comfortable with an edible like a gummy or a capsule. You may also want to consider your budget.

Here are some tips for shopping for CBD: 

  • Verify the source. Check and double-check the brand’s website to find out where they get their CBD. It may be safer to go with domestically produced CBD sourced from American farms.
  • Check the lab test results. It’s important to verify the safety of a product before putting it in your body, so choose a brand that has its products tested by third-party labs and publishes the results on their site. Some even have a QR code linking to those results on the label.
  • Look for satisfaction guarantees. Always check the return policy before you buy, just in case you’re not satisfied with the product. The best CBD oil brands offer some kind of satisfaction guarantee. 
  • Consider the flavor options. CBD is generally suspended in a carrier oil like MCT oil or hemp seed oil which some people find unpleasant. If you don’t like the natural flavor of CBD oil, consider a brand that offers flavored options.
  • Subscribe and save. If you enjoy the benefits of CBD, you may find yourself taking it long-term and it’s well worth looking into subscription options. Many companies offer savings of up to 20% (often with free shipping) for recurring orders. 

In addition to keeping the above things in mind, it’s not a bad idea to check customer reviews for a CBD company before you buy. While you can learn a lot from the company’s history and their published lab test results, other customers are a great source of insight for things like customer service, shipping time, and returns. 

CBD Oil Dosage?

Because CBD oil was only legalized in 2018 with the passing of the United States Agriculture Improvement Act[14], there is relatively little scientific research that has been completed in human subjects. As such, there are no standard dosing regulations for CBD products. Generally speaking, it’s best to start out at a low dose and slowly increase the dosage as needed until you achieve the desired effect. When it comes to how much CBD to take, it’s best to talk to your doctor for dosing recommendations.  

Potential Side Effects of CBD Oil

There is only one form of CBD approved by the U.S. Food and Drug Administration (FDA), a prescription anti-seizure medication called Epidiolex[15]. This drug is designed to treat two rare forms of epilepsy: Lennox-Gastaut syndrome and Dravet syndrome. 

While the FDA hasn’t approved any over-the-counter CBD products, they are generally recognized as safe. That being said, individual reactions may vary, and some people experience mild side effects[16], including changes in mood or appetite, diarrhea, dizziness, drowsiness, dry mouth, nausea, and vomiting.

The Bottom Line 

While more testing is required to verify the benefits of CBD for humans, the current evidence available is promising. Whether you’re aiming for pain relief, trying to improve your sleep, or dealing with more serious issues like seizures, CBD could help. 

Before buying a CBD product, take the time to do your research. Think about what type of product you’re looking for as well as your budget, then do some comparison shopping. Always verify the third-party lab results and follow the dosing instructions carefully. 

Frequently Asked Questions

What is CBD?

Cannabidiol, or CBD for short, is a naturally occurring cannabinoid compound found in the cannabis plant. It is found in the highest concentration in hemp versus marijuana.

Is CBD legal?

Yes, as long as it contains less than 0.3% THC by dry weight. The 2018 Agriculture Improvement Act (Farm Bill) made CBD legal for sale.

How much CBD should I take?

It depends on your tolerance and what you’re treating. CBD products start as low as 10 mg CBD per bottle and go as high as 6,000 mg CBD per bottle, so follow the dosing recommendations on the package.

Is CBD oil safe?

While CBD is not approved by the FDA, it is generally regarded as safe. That being said, some users experience minor side effects[16] like nausea, dizziness, and changes in appetite.


+ 16 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. VanDolah, H.J., Bauer, B.A. and Mauck, K.F. (2019). Clinicians’ Guide to Cannabidiol and Hemp Oils. Mayo Clinic Proceedings, [online] 94(9), pp.1840–1851. Available at: https://www.mayoclinicproceedings.org/article/S0025-6196(19)30007-2/fulltext [Accessed 29 Sep. 2021].
  2. ‌Journal of Dietary Supplements. (2020). Differentiating Full-Spectrum Hemp Extracts from CBD Isolates: Implications for Policy, Safety and Science. [online] Available at: https://www.tandfonline.com/doi/abs/10.1080/19390211.2020.1776806?journalCode=ijds20 [Accessed 29 Sep. 2021].
  3. ‌Grinspoon, P. (2018). Cannabidiol (CBD)-what we know and what we don’t – Harvard Health. [online] Harvard Health. Available at: https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476 [Accessed 29 Sep. 2021].
  4. ‌Mouslech Z;Valla V (2020). Endocannabinoid system: An overview of its potential in current medical practice. Neuro endocrinology letters, [online] 30(2). Available at: https://pubmed.ncbi.nlm.nih.gov/19675519/ [Accessed 29 Sep. 2021].
  5. ‌Darkovska-Serafimovska, M., Serafimovska, T., Arsova-Sarafinovska, Z., Stefanoski, S., Keskovski, Z. and Balkanov, T. (2018). Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases. Journal of Pain Research, [online] Volume 11, pp.837–842. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922297/ [Accessed 29 Sep. 2021].
  6. ‌Rupress.org. (2021). [online] Available at: https://rupress.org/jem/article/209/6/1121/41297/Cannabinoids-suppress-inflammatory-and-neuropathic [Accessed 29 Sep. 2021].
  7. ‌Russo, M., Calabrò, R.S., Naro, A., Sessa, E., Rifici, C., D’Aleo, G., Leo, A., De Luca, R., Quartarone, A. and Bramanti, P. (2015). Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation. Neural Plasticity, [online] 2015, pp.1–6. Available at: https://pubmed.ncbi.nlm.nih.gov/25699191/ [Accessed 29 Sep. 2021].
  8. ‌Depression and Other Common Mental Disorders Global Health Estimates. (n.d.). [online] Available at: http://apps.who.int/iris/bitstream/handle/10665/254610/WHO-MSD-MER-2017.2-eng.pdf.
  9. ‌Blessing, E.M., Steenkamp, M.M., Manzanares, J. and Marmar, C.R. (2015). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics, [online] 12(4), pp.825–836. Available at: https://pubmed.ncbi.nlm.nih.gov/26341731/ [Accessed 29 Sep. 2021].
  10. ‌Linares, I.M., Zuardi, A.W., Pereira, L.C., Queiroz, R.H., Mechoulam, R., Guimarães, F.S. and Crippa, J.A. (2019). Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. Brazilian Journal of Psychiatry, [online] 41(1), pp.9–14. Available at: https://pubmed.ncbi.nlm.nih.gov/30328956/ [Accessed 29 Sep. 2021].
  11. ‌Zanelati, T., Biojone, C., Moreira, F., Guimarães, F. and Joca, S. (2009). Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. British Journal of Pharmacology, [online] 159(1), pp.122–128. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823358/ [Accessed 29 Sep. 2021].
  12. ‌Devinsky, O., Cilio, M.R., Cross, H., Fernandez-Ruiz, J., French, J., Hill, C., Katz, R., Di Marzo, V., Jutras-Aswad, D., Notcutt, W.G., Martinez-Orgado, J., Robson, P.J., Rohrback, B.G., Thiele, E., Whalley, B. and Friedman, D. (2014). Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia, [online] 55(6), pp.791–802. Available at: https://pubmed.ncbi.nlm.nih.gov/24854329/ [Accessed 29 Sep. 2021].
  13. ‌Thiele, E.A., Marsh, E.D., French, J.A., Mazurkiewicz-Beldzinska, M., Benbadis, S.R., Joshi, C., Lyons, P.D., Taylor, A., Roberts, C., Sommerville, K., Gunning, B., Gawlowicz, J., Lisewski, P., Mazurkiewicz Beldzinska, M., Mitosek Szewczyk, K., Steinborn, B., Zolnowska, M., Hughes, E., McLellan, A. and Benbadis, S. (2018). Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial. The Lancet, [online] 391(10125), pp.1085–1096. Available at: https://pubmed.ncbi.nlm.nih.gov/29395273/ [Accessed 29 Sep. 2021].
  14. ‌Congress.gov. (2017). H.R.2 – 115th Congress (2017-2018): Agriculture Improvement Act of 2018. [online] Available at: https://www.congress.gov/bill/115th-congress/house-bill/2 [Accessed 29 Sep. 2021].
  15. ‌Abu-Sawwa, R. and Stehling, C. (2020). Epidiolex (Cannabidiol) Primer: Frequently Asked Questions for Patients and Caregivers. The Journal of Pediatric Pharmacology and Therapeutics, [online] 25(1), pp.75–77. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938286/ [Accessed 29 Sep. 2021].
  16. ‌Cannabis and Cannabinoid Research. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies | Cannabis and Cannabinoid Research. [online] Available at: https://www.liebertpub.com/doi/10.1089/can.2016.0034 [Accessed 29 Sep. 2021].

Medically reviewed by:

Kate Barrington holds a Bachelor’s degree in English and is the published author of several self-help books and nutrition guides. Also an avid dog lover and adoring owner of three cats, Kate’s love for animals has led her to a successful career as a freelance writer specializing in pet care and nutrition. Kate holds a certificate in fitness nutrition and enjoys writing about health and wellness trends — she also enjoys crafting original recipes. In addition to her work as a ghostwriter and author, Kate is also a blogger for a number of organic and natural food companies as well as a columnist for several pet magazines.

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