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Best CBD Oil For Sleep & Insomnia 2023

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cbdfx sleep tincture


  • Broad spectrum CBD (1000mg-4,000mg)
  • 5mg CBN & Melatonin per serving
  • Organic, Non-GMO & Vegan

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Spruce CBD

  • 150mg CBN – The sleep cannabinoid
  • 1,200mg CBD from 200 Year Old Heirloom Strain
  •  High-quality American hemp

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Joy Organics CBD Oil

Joy Organics

  • THC-free products
  • Fast-acting products 
  • Third-party lab testing

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More and more people are using CBD oil to improve their sleep quality. Here’s a look at the best CBD oil for sleep and a buyer’s guide to help you use it.

We’ve all struggled with poor sleep. Whether it’s an occasional restless night or full-blown insomnia, sleeping problems are quite common in our fast-paced, modern lifestyle. 

Research suggests that insomnia affects about 10-15%[1] of the U.S. population and that’s before accounting for other sleep disorders and the odd night of poor sleep.

Many people successfully use CBD oil to improve their nighttime rest. Unfortunately, finding the best CBD oil for sleep can be difficult because the market is filled with thousands of products. 

That’s why we compared dozens of CBD brands to find the top products based on the formula, hemp source, price, third-party testing, company reputation, and other key factors. Read on for our detailed reviews of the 10 best CBD oils for sleep and insomnia in 2022.

10 Best CBD Oils for Sleep & Insomnia on the market in (June. 2023)

CBD Oil For Sleep

CBD oil is a popular natural sleep aid, with early research suggesting that CBD can help you get a better night’s sleep.

Studies show that CBD can help improve your sleep indirectly, by addressing the underlying causes of poor sleep, such as anxiety, stress, pain, and depression. There’s also some evidence that CBD works as a sedative when taken in high doses.

On top of that, CBD is a natural, non-intoxicating substance that’s been shown to be exceptionally safe in numerous studies. 

In contrast, many of the medications used to treat insomnia and other sleep problems can cause serious side effects and are not meant to be used for long periods of time. They also tend to treat the symptoms rather than the root cause of your sleeping problems.

10 Best CBD Oils for Sleep in 2023

CBDfx CBN + CBD Calming Tincture

cbdfx sleep tincture

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See CBDfx Reviews

CBDfx purports to have put its products through eight rounds of testing. CC Testing Labs, an ISO 17025-accredited facility, conducts the testing.

  • This brand carries out extensive and exhaustive third-party testing.
  • The brand offers a 30-day client satisfaction guarantee.
  • The tinctures come with a traceable QR code that allows any user to check the lab reports of the product.
  • It contains CBN, a minor cannabinoid that helps with relaxation and sleep.
  • Returns are only allowed for unopened products.

You can digitally view certificates of analysis (COAs) or scan a QR code on every CBD item for complete transparency. The certification gives the brand a plus as clients can ascertain what they are using in every CBDfx product.

The extraction process starts with Kentucky organic and non-GMO cannabis. They use a CO2 process to extract CBD from hemp. CBDfx plants have been granted Current Good Manufacturing Practices (cGMP) compliance, and strict development and manufacturing standards have been adopted.

Cannabinol (CBN) is purported to improve better sleep. CBN is combined with broad-spectrum CBD and melatonin[2] in this CBDfx tincture. The device is designed to make it easier for people to fall into a deep slumber.

The regular strength version costs around $70 and has 1,000 mg of CBD in a 30-milliliter (ml) container. People can also choose between the different dosage version, which contains 2,000 micrograms in a 60-ml bottle, and the maximum strength variant, which includes 4,000 micrograms (mcg) in a 120-ml bottle.

Spruce CBD 1,200mg CBD & 150mg CBN


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See Spruce CBD Reviews

Spruce is a family-run CBD brand that offers high-quality, third-party lab-tested, full-spectrum CBD oil made from one of the finest, oldest hemp strains in the United States.

  • 150mg CBN – The sleep cannabinoid
  • 1,200mg CBD from 200 Year Old Heirloom Strain
  • High-quality, unique strain of American hemp
  • Costs more than average
  • Only two potencies

Established in 2018, Spruce is a CBD brand based in Raleigh, North Carolina. The company prides itself on making American-made CBD products.

Spruce stands out from the competition in several ways. For starters, it’s a family-run business, which is a rarity in the CBD industry. 

Its CBD is sourced from a time-tested strain of hemp that’s been cultivated in the United States for over two hundred years. This hemp is grown on organic farms in Kentucky and North Carolina.

Spruce is also unique for using a moonshine (alcohol) extraction method to isolate a CBD-rich extract from hemp. Although most CBD companies use CO2 extraction, alcohol extraction is just as safe and effective. 

Spruce’s CBD oil is made with full-spectrum hemp extract, which means it provides all of the cannabinoids, terpenes, and other beneficial compounds found in the plant.

It has a pleasant peppermint flavor and comes in 30 ml bottles with two CBD potencies: 25 mg of CBD per ml (750 mg total) and 80 mg of CBD per ml,(2400 mg total). Spruce CBD Rest contains 1,200mg CBD from 200 Year Old Heirloom Strain and 150mg CBD – The sleep cannabinoid. This makes the brand become more special.

Like all reputable CBD companies, Spruce provides comprehensive third-party test reports to confirm the safety and potency of its products.

Joy Organics CBD

Joy Organics CBD Oil

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Joy Organics specializes in broad-spectrum CBD products, which contain all of the beneficial components of hemp except THC. If you want to maximize the beneficial impact of CBD while completely avoiding THC, this brand is a great choice.

  • THC-free, broad-spectrum formula
  • Comprehensive third-party testing
  • High-quality Colorado hemp
  • Free shipping
  • Low levels of minor cannabinoids

Joy Organics is a family-run brand offering a wide variety of CBD products, including oils, capsules, topicals, and drink mixes. 

All of its offerings are formulated with broad-spectrum hemp extract, which provides CBD and all other beneficial cannabinoids and terpenes naturally present in hemp, except for THC.

This type of extract is ideal for people who prefer to completely avoid THC but want to maximize the beneficial impact of CBD by combining it with other active hemp compounds. 

Joy Organics sources its broad-spectrum CBD from organic hemp cultivated and extracted in Colorado. All of its products are third-party lab tested with the results available online.

Joy Organics’ CBD oil is available in four strengths:

  • 7.5 mg/ml (225 mg CBD total)
  • 15 mg/ml (450 mg CBD total)
  • 30 mg/ml (900 mg CBD total)
  • 45 mg/ml (1350 mg CBD total)

You can also choose from four flavors: natural, tranquil mint, summer lemon, and orange bliss.

Nuleaf Naturals

NuLeaf Naturals Tinctures

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Despite the limited assortment of CBD oil quantities and product varieties; the company is most renowned for creating trustworthy, high-quality products. Every time you place an order, you can be confident that the goods you receive will be of the greatest possible quality.

  • Helpful remedy for sound sleep.
  • Helps mitigate stress.
  • Made with American-grown hemp.
  • Over 200 common compounds were tested in laboratories for efficacy.
  • Priced higher than the rivals.
  • The product line is limited.

Nuleaf Naturals uses a combination of subcritical and supercritical CO2 to extract its products from organically cultivated hemp. NuLeaf Naturals CBD oil for sleep has been processed to extract any plant residue, giving it a lovely amber-gold hue.

You can choose from five distinct volumes:

  • 240 milligrams of CBD per 5 mL bottle
  • 725 milligrams of CBD per 15 mL bottle
  • Each bottle contains 1450 milligrams of CBD in 30 mL.
  • Each 50 mL bottle contains 2425 milligrams of CBD.
  • Per bottle, 100 mL equates to 4850 milligrams of CBD.

Each bottle of Nuleaf Naturals CBN oil for sleep[3] contains 48 mg/mL of CBD, equating to about 1.6 milligrams per drop. Compared to many other CBD oils on the market, this one has a comparatively high potency.

At such potencies, you are bound to fall sound asleep in a matter of minutes.

CBDistillery Full-Spectrum CBD Oil

CBDistillery oil_1

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CBDistillery is one of the most popular CBD brands in the U.S., recognized for its combination of excellent prices, transparency, and efficacy.

  • U.S. Hemp Authority Certified
  • High-quality Colorado hemp
  • Comprehensive third-party testing
  • Competitive prices
  • Lacks flavored options

Established in 2016, Colorado’s CBDistillery has rapidly grown into a top-tier CBD brand. Known for excellent quality and competitive prices, CBDistillery is a great pick when you need a reliable and affordable CBD product.

The company is also fully transparent about its manufacturing process. CBDistillery uses organic, non-GMO hemp cultivated in Colorado extracted with both leading methods (ethanol and CO2) and offers comprehensive third-party test reports.

Additionally, CBDistillery is certified by the U.S. Hemp Authority, which requires hemp producers to adhere to strict manufacturing standards.

The company’s full-spectrum CBD oils are the ideal option for aiding sleep. They come in potencies of 17, 33, 83, and 167 of CBD per ml, adding up to a total of 500-5000 mg of CBD. This makes it easy to find the strength that meets your needs. 

Royal CBD

royal cbd official

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Shop a wide variety of CBD products including oils, Migraines can come on fast and knock you off your feet. Royal CBD oil offers safe and effective relief from serious migraine pain.

  • CBD supported by full-spectrum cannabidiols
  • Sourced from organic hemp
  • Environmentally friendly and sustainably grown
  • Several different concentrations
  • A bit pricer than competitors

Best known for pushing innovation in the CBD industry with its unique product formulations and flavors, CBDfx was founded in 2014 in California. The company offers all kinds of CBD products, including vape juice, topicals, face masks, and even drinks. 

CBDfx’s products are derived from organic hemp grown in Kentucky. They come with third-party test results so you can confirm their potency for yourself.

CBDfx offers a special CBD oil designed specifically for improving sleep. This 30 ml tincture comes in four strengths, providing 500-4000 mg of CBD alongside 150-300mg of CBN, another beneficial cannabinoid that’s believed to help promote and support healthy sleep.

CBDPure CBD Hemp Oil

CBDPure Oil

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CBDPure is a solid pick for anyone who wants a straightforward, unprocessed full-spectrum CBD oil without any bells and whistles. 

  • A full-spectrum formula rich in minor cannabinoids
  • Comprehensive third-party testing
  • Unflavored and mixed with hemp seed oil
  • 90-day satisfaction guarantee
  • A basic website that lacks detailed info
  • Low CBD potency

CBDPure was established in 2016 in Washington and offers a simple lineup of full-spectrum CBD products: oil, capsules, cream, and a tincture for pets.

The company’s main focus is on natural, unprocessed CBD products. That’s why CBDPure doesn’t put any flavoring or additives into its oils.

All you’re getting is an effective full-spectrum CBD extract rich in all of the minor cannabinoids found in hemp, dissolved in an equally unprocessed hemp seed oil. The CBD is sourced from organic hemp grown on Colorado and Washington farms.

CBDPure’s CBD hemp oil comes in 60 ml bottles and three strengths: 300 mg (5 mg/ml), 600 mg (10 mg/ml), and 1000 mg (17 mg/ml). You can easily look up all of the third-party test results to confirm their potency and safety.

Charlotte’s Web

Charlotte’s Web

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As far as reputation goes, you won’t find many CBD companies as well-known, established, and respected as Charlotte’s Web.

  • U.S. Hemp Authority Certified
  • Comprehensive third-party testing
  • Established, respected brand
  • Multiple potencies, sizes, and flavors
  • Third-party test results only available after the purchase

Charlotte’s Web is a pioneer in the American CBD industry. It was founded in 2013 and gets its name from a special strain of hemp. The company’s founders developed and used this hemp to help Charlotte Figi, a young girl who was suffering from a rare type of epilepsy. 

Since then, Charlotte’s Web has grown into one of the biggest and most reputable brands in the CBD industry and offers a complete lineup of CBD products. 

The company derives CBD from organic hemp plants grown in Colorado, Oregon, and Kentucky. It requires the soil and the plants themselves to be tested for contaminants and consistent cannabinoid levels.

Charlotte’s Web is also certified by the U.S. Hemp Authority, a program that checks for adherence to strict hemp manufacturing standards, and has its finished products tested by a third-party lab.

The company’s full-spectrum CBD oil is available in four low-to-high potencies: 

  • 7 mg/ml
  • 17 mg/ml
  • 50 mg/ml
  • 60 mg/ml

They come in three bottle sizes: 10 ml, 30 ml, and 100 ml adding up to a total of 170-6000 mg of CBD. You can also choose between multiple flavors: natural, lemon twist, orange blossom, and mint chocolate. 

Medterra CBD Oil

Medterra oil

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If you’re looking for a pure, affordable CBD oil without THC or any other active ingredients, Medterra is a solid pick.

  • Pure CBD isolate formula
  • Exceptionally low prices
  • U.S. Hemp Authority Certified
  • Comprehensive third-party testing
  • No flavored options

Medterra is a reputable CBD company that has all the signs of a top-tier brand. It offers a wide variety of affordable CBD products sourced from organic, non-GMO hemp grown in Kentucky. 

Medterra uses the industry gold-standard CO2 extraction method and completely removes THC from all of its CBD preparations.  

All of its products come with detailed third-party lab test reports for potency and contaminants. Better yet, Medterra is certified by the U.S. Hemp Authority, which highlights compliance with stringent hemp manufacturing standards. 

The company’s CBD tincture is made with pure CBD isolate, which means it contains no other cannabinoids or other hemp compounds. It’s available in potencies of 17 mg, 33 mg, and 100 mg of CBD per ml, providing a total of 500, 1000, or 3000 mg.

Wonderfeel Evening CBD Extra Strength

Wonderfeel Evening CBD

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Wonderfeel CBD oil is a high-strength CBD product that contains 1350 mg CBD in it. It comes in a 30ml bottle with an easy-to-use dropper.

  • Low-calorie product
  • High-strength CBD oil
  • Has a good taste
  • Contains Bisabolol, Linalool, and Myrcene
  • Has CBG and CBN
  • Can cause lightheadedness
  • Makes one drowsy

Enjoy better sleep by taking this high-strength CBD oil. It also contains CBG and CBN to help you relax and fall asleep[]. On top of that, thanks to its high potency, you can enjoy uninterrupted sleep throughout the night.

This CBD product contains CBD oil made using 100% natural ingredients. It’s free of artificial flavorings and additives that can interfere with its potency.

As a high-strength product (1350mg), the manufacturer recommends taking ½ a dropper that contains 22.5 mg. The maximum dose of Wonderfeel CBD oil is 200 mg per day.

This is an easy-to-use CBD oil you can swallow or add to food or drink. Some folks prefer to use CBD oil topically, which is also a great way to benefit from its high potency. On top of that, it’s made using 100% natural ingredients, which is important for a CBD product.


Endoca CBD Oil

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Endoca is one of the oldest and most established CBD companies out there, recognized for its rigorous quality control and exceptional full-spectrum hemp products.

  • A full-spectrum formula rich in minor cannabinoids
  • Grows and extracts its own hemp
  • Third-party and in-house testing
  • Established CBD brand
  • Strong earthy flavor
  • Only two potencies

Endoca is a Danish CBD company founded in 2010, making it one of the first CBD brands in the world. Today, it remains a top-tier choice.

The biggest strength of Endoca is that it controls every step of the manufacturing process. Whereas most CBD brands buy hemp or finished CBD extracts from other producers, Endoca 

grows and extracts its own organic, non-GMO hemp plants in Denmark. 

Endoca also tests its plants and finished extracts in addition to comprehensive third-party testing.

Additionally, Endoca is known for producing some of the best full-spectrum CBD products out there. If we look at its third-party lab reports, we can see the presence of many minor cannabinoids aside from CBD, which is a sign of superb hemp plants and an effective extraction process.

Endoca’s oils come in 10 ml bottles containing 300 mg (10 mg/ml, medium potency) or 1500 mg of full-spectrum CBD (150 mg/ml, high potency). They’re blended with hemp seed oil without any flavoring.

CBD For Sleep & Insomnia: Buyer’s Guide

CBD, short for cannabidiol, is one of over 120 active compounds known as cannabinoids present in the cannabis plant. Unlike THC, the cannabinoid you’re likely familiar with, CBD doesn’t make you high. 

Decades of studies have concluded that CBD is a remarkably safe compound with mostly minor side effects. Even the World Health Organization concluded in their 2018 report [4] that CBD is well-tolerated and has a good safety profile.

CBD has grown incredibly popular as a health and wellness supplement. It’s taken for many common health issues, including insomnia and other sleeping problems.

How can CBD aid your sleep? What does the research say? When should you take CBD and in what form?

Let’s answer these and other common questions to help you get the most out of cannabidiol.

How Can CBD Help With Sleep?

Research suggests that CBD can help with insomnia and other sleep disorders by helping with their underlying causes.

Numerous studies have shown that CBD:

Since some of these issues are often at the root of bad sleep, this means CBD can indirectly alleviate insomnia and related problems. In addition, a common side effect [8] of CBD is sedation or causing sleepiness.

CBD produces many of its beneficial effects by interacting with the endocannabinoid system (ECS). 

Composed of endocannabinoids made in your body, special enzymes, and cannabinoid receptors, this system works to maintain a healthy state of balance in your body called homeostasis. It regulates many critical processes, including the sleep-wake cycle [9]

CBD can support the balancing effects of the ECS on this cycle by suppressing an enzyme [10] that breaks down your body’s endocannabinoids. Keep in mind that cats, dogs, and many other animals also have an ECS, so they can benefit from CBD oil too.

Additionally, CBD has been shown to work through other ways, such as interacting with your serotonin receptors [11], which play a role in anxiety, mood, and other processes.

The Research Evidence

Although human research is still in its early stages, several small studies and reports have found that CBD can improve sleep. Here’s a summary of the most notable findings:

  • In a study of 72 people with anxiety and sleep issues, 67% reported better sleep [12] during the first month of taking CBD.
  • In a study of 21 people suffering from post-traumatic stress disorder (PTSD), 38% reported better sleep [13] after using CBD.
  • In a case report of four Parkinson’s disease sufferers, CBD improved REM sleep behavior disorder [14] (RBD), a condition where people act out intense dreams.
  • CBD oil improved sleep in a case report of a woman with restless leg syndrome [15], a condition where you have a strong urge to move your legs.

Does CBD Make You Sleepy?

Studies using high doses (300 mg or more per day) of pure CBD have reported side effects such as drowsiness and fatigue. However, the average person is unlikely to experience these effects because most people use much smaller doses.

CBD Oil Dosage For Sleep

There’s no ideal dosage of CBD oil for sleep that will work for everyone. It depends on your body weight, genetics, your precise issue, its severity, and even the type of CBD product you’re taking.

That’s why it’s best to follow the “start low and go slow [16] method where you begin with a small dose of CBD, like 10-15 mg, and wait a few hours to assess the effects. 

If you don’t notice any change, you can incrementally raise your CBD dose over time, until you settle on the amount that gives you the desired effects.

Best CBD Products For Sleep

Although it’s the most popular, CBD oil is not the only way to use CBD to enhance your sleep. You can also take CBD orally in the form of capsules and gummies or vape CBD e-liquids. 

CBD Oil For Sleep

CBD oil is usually the best way to use CBD. First and foremost, CBD oil allows you to absorb cannabidiol directly into the blood vessels under your tongue (sublingual absorption). This is far more efficient than oral absorption, which is when you ingest CBD and it goes through your digestive system.

Also, CBD oil makes it easy to control your dose. It should start working relatively quickly and its effects can last for many hours.

CBD Capsules And Gummies For Sleep

Capsules and gummies are another way to use CBD for sleep because they’re incredibly convenient and easy to use. Besides, gummies make taking CBD a pleasant experience thanks to their delicious taste. 

Having said that, CBD and other cannabinoids have low oral absorption [17] because they have to pass through your digestive system before reaching the bloodstream, with much of the CBD being lost along the way. 

That’s why CBD oil — which uses the sublingual method — produces greater effects than capsules and gummies.

They also take longer to start working because of the time it takes the CBD to get through the digestive tract and the liver. As such, the effects will kick in faster if you take capsules or gummies on an empty stomach versus after a large meal. 

CBD Vape Juice For Sleep

Another increasingly popular alternative to CBD oil is to vape CBD-infused e-liquid. When you vape CBD, its effects kick in right away, which is great when you want immediate relief. 

However, vaping has some downsides: its effects last the shortest of any CBD product and there are some health risks associated with vaping [18]

How To Use CBD For Sleep

After you’ve chosen your CBD product, you usually want to take CBD before you head to bed, to give it time to start working right as you’re falling asleep. 

However, the exact time will depend on how you take CBD. For example, if you vape CBD, you can theoretically use it right before going to bed, whereas if you use capsules, you may need to give CBD more time to start working.

Frequently Asked Questions

Will it cure my sleepless nights?

It will help you direct your body into a better and more fluent nighttime sleep schedule and in order to do this, you will need to pinpoint your sleeping issues.

What strength should I use?

It is recommended that you start with the lowest dosage and then work your way up from there if the low dosage doesn’t produce the results that you need.

How quickly will I notice a difference?

The speed of change depends on how CBD oil interacts with your body’s chemistry and homeostasis.

What method of extraction is the best method?

There are multiple methods of extraction, however, the full-spectrum extraction method allows the oil to retain all of its amino acids, terpenes, and cannabinoids.

+ 18 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Kaur, H., Spurling, B.C. and Bollu, P.C. (2022). Chronic Insomnia. [online] Nih.gov. Available at: https://www.ncbi.nlm.nih.gov/books/NBK526136/.
  2. ‌NORML. (2022). Study: Insomnia Patients Respond Favorably to Concurrent Use of CBD and Melatonin – NORML. [online] Available at: https://norml.org/news/2022/02/17/study-insomnia-patients-respond-favorably-to-concurrent-use-of-cbd-and-melatonin/.
  3. Corroon, J. (2021). Cannabinol and Sleep: Separating Fact from Fiction. Cannabis and Cannabinoid Research. [online] doi:10.1089/can.2021.0006.
  4. Geneva (2018). CANNABIDIOL (CBD) Critical Review Report Expert Committee on Drug Dependence Fortieth Meeting. [online] Available at: https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf.
  5. Blessing, E.M., Steenkamp, M.M., Manzanares, J. and Marmar, C.R. (2015). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics, [online] 12(4), pp.825–836. doi:10.1007/s13311-015-0387-1.
  6. Sales, A.J., Crestani, C.C., Guimarães, F.S. and Joca, S.R.L. (2018). Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels. Progress in Neuro-Psychopharmacology and Biological Psychiatry, [online] 86, pp.255–261. doi:10.1016/j.pnpbp.2018.06.002.
  7. Vučković, S., Srebro, D., Vujović, K.S., Vučetić, Č. and Prostran, M. (2018). Cannabinoids and Pain: New Insights From Old Molecules. Frontiers in Pharmacology, [online] 9. doi:10.3389/fphar.2018.01259.
  8. Scuderi, C., Filippis, D.D., Iuvone, T., Blasio, A., Steardo, A. and Esposito, G. (2008). Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. Phytotherapy Research, [online] 23(5), pp.597–602. doi:10.1002/ptr.2625.
  9. Babson, K.A., Sottile, J. and Morabito, D. (2017). Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Current Psychiatry Reports, [online] 19(4). doi:10.1007/s11920-017-0775-9.
  10. Leweke, F.M., Piomelli, D., Pahlisch, F., Muhl, D., Gerth, C.W., Hoyer, C., Klosterkötter, J., Hellmich, M. and Koethe, D. (2012). Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Translational Psychiatry, [online] 2(3), pp.e94–e94. doi:10.1038/tp.2012.15.
  11. Campos, A.C. and Guimarães, F.S. (2008). Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology, [online] 199(2), pp.223–230. doi:10.1007/s00213-008-1168-x.
  12. Shannon, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente Journal, [online] 23. doi:10.7812/tpp/18-041.
  13. Elms, L., Shannon, S., Hughes, S. and Lewis, N. (2019). Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series. The Journal of Alternative and Complementary Medicine, [online] 25(4), pp.392–397. doi:10.1089/acm.2018.0437.
  14. Chagas, M.H.N., Eckeli, A.L., Zuardi, A.W., Pena-Pereira, M.A., Sobreira-Neto, M.A., Sobreira, E.T., Camilo, M.R., Bergamaschi, M.M., Schenck, C.H., Hallak, J.E.C., Tumas, V. and Crippa, J.A.S. (2014). Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson’s disease patients: a case series. Journal of Clinical Pharmacy and Therapeutics, [online] 39(5), pp.564–566. doi:10.1111/jcpt.12179.
  15. Megelin, T. and Ghorayeb, I. (2017). Cannabis for restless legs syndrome: a report of six patients. Sleep Medicine, [online] 36, pp.182–183. doi:10.1016/j.sleep.2017.04.019.
  16. Lucas, C.J., Galettis, P. and Schneider, J. (2018). The pharmacokinetics and the pharmacodynamics of cannabinoids. British Journal of Clinical Pharmacology, [online] 84(11), pp.2477–2482. doi:10.1111/bcp.13710.
  17. Bruni, N., Della Pepa, C., Oliaro-Bosso, S., Pessione, E., Gastaldi, D. and Dosio, F. (2018). Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules, [online] 23(10), p.2478. doi:10.3390/molecules23102478.
  18. PUBLIC HEALTH CONSEQUENCES OF E-CIGARETTES CONCLUSIONS BY LEVEL OF EVIDENCE CONCLUSIVE EVIDENCE. (2018). [online] Available at: https://nap.nationalacademies.org/resource/24952/012318ecigaretteConclusionsbyEvidence.pdf.
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Medically reviewed by:

Victor Nguyen

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Medically reviewed by:

Victor Nguyen

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