A lupus diagnosis will be devastating. The illness causes the body’s immune system to attack its own tissues and might have an effect on internal organs (including the brain, heart, and lungs) which may begin to deteriorate. Lupus flare-ups will leave patients so worn out and in pain that they’re unable to do the simplest of things, like walk, cook, or read. Several can’t go outdoors without layers of sunblock, because the disease will make them extremely vulnerable to sunburn.
Lupus affects approximately 240,000 individuals within the United States, and yet at present doctors neither know the precise cause nor have a cure. Instead, current treatments concentrate on improving quality of life by controlling symptoms and minimizing flare-ups to lessen the risk of organ damage.
“The landscape for treatment of lupus could be a bit bleak,” a statement by Fotios Koumpouras, MD, a rheumatologist, and director of the Lupus Program at Yale Medicine. “A multitude of drugs have failed in the last ten to 15 years. Most of the drugs we use are being repurposed from other conditions and are not unique to lupus. Many of them can’t be used during pregnancy, which is a problem because lupus mostly affects young women. All of these issues create the impetus to find new and more effective therapies.”
This is why he’s exploring an unconventional candidate for the best lupus treatment option: CBD (one of the chemicals found within the marijuana plant).
CBD oil benefits for lupus
CBD is a form of a cannabinoid called “cannabidiol.” Cannabinoids are a type of chemical that binds to (CB1 and CB2) receptors found throughout the body. CB1 receptors are mostly located in the nervous system, connective tissues, gonads, glands, and organs; CB2 receptors are primarily found in the immune system, along with the spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands, and reproductive organs. (Collectively this is called the endocannabinoid system.)
What these cannabinoids do after they bind to the receptors depends on which receptor is activated, and therefore will produce effects starting from the firing of neurotransmitters (the chemical messengers sent from the brain to the remainder of the body) that alter mood, to reducing inflammation and promoting digestion.
Our bodies produce cannabinoids, but they can also be found in nature, most abundantly in the marijuana plant. The two most well-known kinds of cannabinoids within the marijuana plant are THC (tetrahydrocannabinol) and CBD (cannabidiol).THC binds to both the CB1 and CB2 receptors and is responsible for many of the well-known psychoactive impacts of marijuana, like euphoria, increased heart rate, slower reaction times, and red eyes.
CBD, on the other hand, binds only with CB2 receptors, leading to the production of a series of proteins to lessen inflammation. (These proteins are known as “resolvins” because they appear to resolve inflammation.)
Fotios Koumpouras, MD, is researching CBD, one of the cannabinoids within the marijuana plant that’s believed to reduce inflammation while not producing the psychoactive effects related to THC. “Reducing inflammation is crucial for patients with lupus,” he says.
This is what caught Dr. Koumpouras’ eye and is looking for new lupus treatment. Reducing inflammation is crucial for patients with lupus because it’s what causes the buildup of scar tissue in vital organs which will eventually lead to their deterioration and malfunction, he says. Unfortunately, none of the lupus drugs on the market are uniformly effective.
In 2018, Dr. Koumpouras joined a multi-site randomized clinical test that aims to recruit a hundred participants to test whether or not a drug-using synthetically created CBD (called Lenabasum) will help ease pain and inflammation in patients with lupus. Participants will receive Lenabasum or a placebo for nearly three months and will continue to be monitored for pain and inflammation levels, as well as lupus disease activity. The study is in progress, but Dr. Koumpouras anticipates that it’ll wrap up by early next year.
From recreational drug to medicine
Dr. Koumpouras’ excitement over the new drug comes at a time when products containing CBD have flooded supermarkets, tagged with claims that they treat everything from back pain to a sleep disorder. Although CBD isn’t yet approved by the FDA, the promotion around it stems from the popularity of the marijuana plant it’s derived from.
Marijuana has been both celebrated and shunned throughout its history in the U.S. Once targeted in the “war on drugs” campaign in the 1980s, marijuana began to gain some foothold of societal acceptance in the mid-1990s when California legalized it for medical use. Since then, claims that the plant could treat a wide range of medical problems, such as inflammation, pain, and even epileptic seizures, are widely covered by news outlets (legitimate and otherwise). At present, 33 states, and the District of Columbia, have decriminalized the drug for medicinal use.
Scientists and researchers are studying these claims. One large review of those studies was published in 2017, when the National Academies of Sciences, Engineering, and Medicine released a report detailing the potential health effects of cannabis and cannabinoids. A committee of 16 experts from a variety of scientific and medical fields analyzed more than 10,000 scientific abstracts, determining there is “conclusive or substantial evidence” supporting the use of cannabis or cannabinoids for chronic pain in adults, multiple sclerosis-related stiffnesses and muscle spasms, as well as chemotherapy-induced nausea and vomiting.
The researchers additionally found “moderate” proof that cannabis or cannabinoids reduce sleep disturbances in people with an obstructive sleep disorder, fibromyalgia, chronic pain, and multiple sclerosis. However, there are no randomized double-blind clinical trials proving marijuana’s effectiveness in patients.
Marijuana remains stigmatized as a recreational drug. That may be, in part, why CBD entrepreneurs position their products as containing an all-natural chemical with all the advantages of marijuana, however without the dissociative effects of THC—something that might be more easily accepted by the public.
But whether CBD truly offers those benefits in a certain way remains to be seen. Only a few studies—small ones—have definitively proven the effectiveness of CBD. To date, the only FDA-approved medication containing CBD is Epidiolex, a medication used to treat two rare forms of severe epilepsy—Lennox-Gastaut syndrome and Dravet syndrome, both of which begin mostly in infancy and early childhood.
In a group of 3 clinical trials, Epidiolex appeared to reduce the number of seizures certainly. And yet, Vinita Knight, MD, a Yale medicine pediatric neurologist, states that her patients who take Epidiolex have had mixed results. Some have had reductions in seizures and others haven’t shown much improvement. “We’re not seeing as much success as what’s been reported on Facebook and Twitter,” she says, but adds that so far it has only been prescribed for children with the most debilitating and difficult-to-treat seizures.
In addition, some researchers believe that CBD works most effectively in combination with other cannabinoids and compounds found in the marijuana plant, in what is known as the “entourage effect.” Thus, it would be less effective as an isolated chemical in pill type, but that, too, remains on trial.
But these questions are why Dr. Koumpouras is studying on a compound that, until recently, few have studied. His research is one of many new studies at Yale and elsewhere looking at CBD for use in treating everything from Crohn’s disease to psoriatic arthritis, and he hopes that this new data will be used to help paint a more complete picture about the chemical for future treatment options. “The more data the better,” he says. “The more we’re able to make informed decisions.”
How much cbd oil to take for lupus?
Once you have worked a treatment plan, the doctor should recommend a suitable dosage for your needs. CBD dosages for Lupus treatment are not a one-size-fits; experts recommend a baseline of 10-20 mg per day, which is equivalent to the ration of 1:6mg for every 10 pounds of body weight.
Despite the few clinical studies about CBD treatment for Lupus, there is a growing body of work exploring how cannabinoids affect the immune system of an individual with Lupus. This focus on the immune system is critical as it enables pharmaceuticals to develop drugs that mimic Lupus treatment.
An in-depth study of the immune system and the role of the endocannabinoid system occurred in 2009, where researchers learned a few things about CBD oil and lupus. First, cannabinoids tested on other autoimmune disorders like colitis, rheumatoid arthritis, and multiple sclerosis show that they protect the patient from pathogenesis by inducing a range of inflammatory pathways.
Secondly, cannabinoids suppress the inflammatory response and relieve the symptoms of the disease. The properties of cannabinoids are mediated using different pathways, e.g., the suppression of chemokines and cytokines at the inflammatory sites, induction of apoptosis in activated immune cells, and upregulation of the T cells.
3 Best CBD oil for lupus
1. CBD Living
Affordable, there is quite a gap in mg of CBD per dollar from the smallest bottle to the largest, so it may be worth using the 1000mg version if you are sure that the brand offers high-quality products.
- Third-party lab tested
- Great product range
- Side effects in their CBD water
- Kind of expensive
CBD Living was lab testing other CBD company’s products and found that many of those product claims were false and did not live up to the hype. So in 2013, a group of scientists and business leaders came together to form what is now CBD Living. Their product is good for reducing lupus symptoms and treat certain kinds of illnesses.
CBD Living is now a global company reaching people who need CBD around the globe. They claim that their CBD merchandise is superior to other CBD brands on the market and a large part of that reason is due to their nanotechnology manufacturing method. This is the main reason why using CBD Living oil has great effects in treating lupus and other related diseases.
Their research and implementation of the nanotechnology manufacturing process are unique because it reduces the CBD molecules to a very small size and does not require the use of any emulsifiers to accomplish this. The advantage that this provides to the buyer of the CBD product is that it lets the body to absorb and utilize the CBD molecules way more efficiently. This translates into a CBD product that works quickly and is more effective.
2. Joy Organics
The active ingredient, cannabinoid emulsion droplets, are just 25 nanometers; In layman’s terms, it means they are far more effective than the average because your endocannabinoid system is exposed to a greater percentage of CBD.
- Third-party labs tested
- All products are processed thoroughly
- Kind of expensive
The Farm Bill of 2018, which was signed into law by the President in December 2018, has provided the CBD industry with an enormous boost. Thanks to the new legislation, it is federally legal to grow industrial hemp anywhere in the United States. Basically, if the hemp has a THC content of less than 0.3%, it is legal.
It is a family-run business named after its founder, Joy Smith. Along with her husband Todd, and children, Gerrid, Danielle, and Hannah, and son-in-law, Josh, Joy has grown her business to the extent where it has physical stores in three locations: Deer Park, Illinois; Austin, Texas; and Fort Collins, Colorado.
There are extra ingredients depending on the flavor, together with MCT oil, grape seed oil, peppermint oil, stevia, and orange essential oil. Joy Organics recommends taking 1 ml of oil per day as a starting point which implies a bottle lasts 30 days. If you’ve got chronic pain, maybe it’s value investing in the largest bottle as it provides you with 50mg per serving.
You can use cbd product from Joy Organics if you want fast relief for lupus and other diseases with the best organic product with approved research of having no side effects. They are now widely known, and a lot of people put their trust in this brand. The quality of the CBD oil is beyond question, and if you don’t believe it, check out the results of third-party lab testing which are available on the website.
3. Green Garden Gold
They provide foremost testing for numerous materials, such as metals, mold, E. Coli, listeria, and different harmful contaminants.
- Third-party lab approved
- High-grade hemp products
- Limited international shipping
- Limited Information
Green Garden Gold sells a great array of CBD oils. Their oils are available in multiple formulations. They offer an advanced Care CBD Oil that’s vegetable glycerin (VG) mixed. They also have two different varieties: MedPac CBD Oil (MCT Coconut Oil) and Real terpene CBD Tinctures.
Not only do they sell quality, traditional CBD oils, they also have a one-to-one CBG. This product includes 500mg of CBD, as well as 500mg of CBG.
They offer a range of potencies, from 200mg to 6000mg. They utilize only natural flavors and ingredients along with expertly cultivated hemp. We liked that their oils allow individuals to adjust their CBD intake according to their situation or particular concerns.
A lot of research on this product proves that if you use CBD oils from them to treat lupus will result to amazing results you may not expect. A lot of feedback from several people who suffers a similar case choose their product and saw great results. You can check their website for customer support or send a message through their email address
Frequently Asked Questions
Finding the right strain can be a process of trial and error. The strain that works best for one patient may not provide the same benefits or success to another. Some patients respond better to CBD oils or a strain with a high-CBD to THC ratio, while others prefer equal amounts of THC to CBD. Other patients respond better to a high-THC strain of cannabis.
Research shows that Cannabidiol also slows down T-cell production and suppresses immune system memory, meaning that it could cut down on the likelihood of future autoimmune attacks. It has also been found to increase the expression of genes that deal with oxidative stress, which may reduce cell damage from autoimmune attacks.
The foods which several sufferers find contribute to signs include nightshade vegetables like potatoes, peppers, eggplant, and tomatoes. Alfalfa has been reported to increase muscular pain and general fatigue and garlic boost the immune system, something which no individual with lupus needs.