07:17am Friday 18 August 2017

Skin Microbes Trigger Specific Immune Responses

New research in mice shows that the immune system in the skin develops distinct responses to the various microbes that naturally colonize the skin, referred to as commensals. A team led by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, found that each type of microbe triggers unique aspects of the immune system, suggesting that immune cells found in the skin can rapidly sense and respond to changes in microbial communities. These findings help clarify the protective role of skin commensalsand may help explain how variation in the microbes at different skin sites contributes to skin disorders.

The skin is home to diverse microbial communities that can change over time. In the current study, investigators found that colonizing mice with different commensals leads to production of commensal-specific immune cells. They describe in detail how the common skin commensal Staphylococcus epidermidis enhances immune responses against pathogens without causing inflammation. Colonizing the skin of mice with S. epidermidis increased the number of CD8+ T immune cells, which produced the chemical messenger IL-17A. Dendritic cells, another type of immune cell, played a key role in generating this specific, non-inflammatory response. Mice colonized with S. epidermidis were protected against infection with a disease-causing fungus. Depleting CD8+ T cells or neutralizing IL-17A removed this protective effect.
The ability of different microbes to trigger distinct aspects of the immune system without causing inflammation opens the possibility of discovering new adjuvants—immune-boosting substances that may be added to vaccines or medications. Future research will focus on identifying specific chemical messengers and understanding how they stimulate the immune system.
S Naik, N Bouladoux et al. Commensal-dendritic cell dialogue specifies a unique protective skin
immune signature. Nature DOI: 10.1038/nature14052 (2014).
Yasmine Belkaid, Ph.D., chief of the Mucosal Immunity Section in NIAID’s Laboratory of Parasitic Diseases and senior author of the paper, is available for comment.
To schedule interviews, please contact Hillary Hoffman, (301) 402-1663, niaidnews@niaid.nih.gov.
The study was conducted by investigators at NIAID, the National Human Genome Research Institute and the National Cancer Institute, all components of NIH, and their collaborators.


NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at www.niaid.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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