Using an advanced spectroscopic technique, the study has involved mapping the interactions between a common carbohydrate that lines human cells and the whole virus.
‘These carbohydrates are essential for rotavirus to recognise human cells and the latest outcomes will speed up the development of
relevant therapies to combat the virus,’ said Institute director Professor Mark von Itzstein.
He said the new research, which is published in world-leading scientific journal Angewandte Chemie, ‘demonstrates how these carbohydrates which are present on human cells interact with the rotavirus particle and serve as an initiation signal for infection and establishment of disease.
‘To develop new anti-viral drugs, we must first understand how the virus binds and infiltrates cells in the human body,’ said Professor von
Rotaviruses are thought to infect the bodies by sticking to sugars that are attached to the surface of our intestinal cells. They then enter cells and reproduce rapidly causing illness.
‘This discovery will advance research in the design and synthesis of new drugs that may stop infection by rotavirus, by exploiting these
recognition elements of the virus,’ said Professor von Itzstein.
The rotavirus is a leading cause of gastroenteritis. Globally approximately 600,000 children under the age of five die from rotavirus-induced diarrhoea each year
Rotavirus infection is estimated to be responsible for 33 per cent of all
hospitalisations, including 10,000 per annum in Australia, due to rotavirus- induced diarrhoea.
At Griffith University, we have the expertise at our Institute for Glycomics to undertake potentially life-saving research into rotavirus if we can find philanthropic partners willing to take the journey with us.
A pre-release of the research abstract can be found at: