04:33am Friday 22 September 2017

How Campylobacter grows in the gut could be key to its eradication from poultry

Campylobacter jejuni is the most common cause of foodborne illness in the UK, responsible for an estimated 400,000 cases each year. Although deaths from Campylobacter infection are rare, the annual cost to the UK economy is over £500M. The main source of the Campylobacter is poultry meat. Although this bacterium does not cause disease in poultry, it does contaminate the carcass and so can enter the human body as a result of poor kitchen hygiene and improper cooking.

Campylobacter cells dividing. Image: Mary Parker, IFR

Campylobacter cells dividing. Image: Mary Parker, IFR

Reducing the levels of Campylobacter in the food chain, and ultimately the incidence of Campylobacter infection in humans, is an aim of the Biotechnology and Biological Sciences Research Council, Defra and the Food Standards Agency, and to help achieve this, it is essential that we understand the biology of Campylobacter, and how it survives in the guts of both birds and mammals.

The guts of both birds and humans contain large populations of bacteria that are essential to digestion and wellbeing. There is keen competition between different bacterial species for available nutrients. Within this, Campylobacter occupies a specific niche that allows it to thrive. While some bacteria produce lactate as a result of their own metabolism, Campylobacter can use this lactate as a source of carbon and energy.

This was opposite to what was predicted based on the gene content of the bacterium, and could point to a way of controlling Campylobacter. Publishing in the journal Environmental Microbiology, the IFR and University of Sheffield have shown that Campylobacter has two new enzyme pathways for the metabolism of lactate. The presence of these novel pathways may allow for designing targeted approaches to eliminate Campylobacter from poultry, without affecting the beneficial microflora in the poultry gut.

ENDS

Notes to editors

Reference: Thomas, M. T., Shepherd, M., Poole, R. K., van Vliet, A. H. M., Kelly, D. J. and Pearson, B. M. (2011), Two respiratory enzyme systems in Campylobacter jejuni NCTC 11168 contribute to growth on L-lactate. Environmental Microbiology, 13: 48-61. doi: 10.1111/j.1462-2920.2010.02307.x

About BBSRC

BBSRC is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £470M in a wide range of research that makes a significant contribution to the quality of life in the UK and beyond and supports a number of important industrial stakeholders, including the agriculture, food, chemical, healthcare and pharmaceutical sectors.

BBSRC provides institute strategic research grants to the following:

  • The Babraham Institute
  • Institute for Animal Health
  • Institute for Biological, Environmental and Rural Studies (Aberystwyth University)
  • Institute of Food Research
  • John Innes Centre
  • The Genome Analysis Centre
  • The Roslin Institute (University of Edinburgh)
  • Rothamsted Research

The Institutes conduct long-term, mission-oriented research using specialist facilities. They have strong interactions with industry, Government departments and other end-users of their research.

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