12:21pm Sunday 19 November 2017

New insights into Campylobacter food poisoning bug

Converting nutrients into energy is essential to all forms of life, and without this process, known as respiration, life would not exist in harsh and hostile conditions. This holds true for the foodborne bacterial pathogen Campylobacter, which colonises the intestines of poultry. In this environment it uses organic acids produced by other bacteria to respire and thrive. Campylobacter needs selenium to make the formate dehydrogenase enzyme required for this respiration, but it is not known how selenium is acquired or metabolised by Campylobacter or many other bacteria.

New research from the group of Dr Arnoud van Vliet at the Institute of Food Research, strategically funded by the Biotechnology and Biological Sciences Research Council, has resulted in the identification of two Campylobacter genes which are required for the formation of the formate dehydrogenase enzyme. Inactivation of these two genes blocked the formation of the formate dehydrogenase enzyme, but when the bacteria were supplemented with extra selenium, they were able to synthesize the enzyme again, suggesting that the two Campylobacter genes are involved in selenium metabolism. As it was previously shown that the lack of formate dehydrogenase affects the ability of Campylobacter to colonise the chicken gut, this may open up possibilities to target this pathway for antimicrobial purposes. In addition, as these selenium metabolism genes and the formate dehydrogenase enzyme are also present in other important foodborne pathogens like Salmonella and E. coli, it may be possible to extend such investigations to other areas of food safety.

“Selenium metabolism is still poorly understood in bacteria, and its role in important foodborne pathogens like Campylobacter is not yet appreciated fully”, said Dr van Vliet. “With the identification of these two genes essential for formate respiration, we now hope to have a tool to generate knowledge that helps us get a better understanding of what makes Campylobacter so good in colonising the chicken gut and cause disease in humans. Such knowledge is essential if we want to achieve the ultimate goal of reducing the impact of Campylobacter in the food industry.”

ENDS

About BBSRC

BBSRC invests in world-class bioscience research and training on behalf of the UK public. Our aim is to further scientific knowledge, to promote economic growth, wealth and job creation and to improve quality of life in the UK and beyond.

Funded by Government, and with an annual budget of around £445M, we support research and training in universities and strategically funded institutes. BBSRC research and the people we fund are helping society to meet major challenges, including food security, green energy and healthier, longer lives. Our investments underpin important UK economic sectors, such as farming, food, industrial biotechnology and pharmaceuticals.

For more information about BBSRC, our science and our impact see: www.bbsrc.ac.uk.
For more information about BBSRC strategically funded institutes see: www.bbsrc.ac.uk/institutes.

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