In the current issue of Science, Michigan State University researchers led a study that revealed how a bacteria flips a DNA switch to go from an upstanding community member in the gut microbiome to deadly killer in insect blood.
Todd Ciche, assistant professor of microbiology and molecular genetics, has seen variants like this emerge sometimes by chance resulting in drastically different properties, such as being lethal to the host or existing in a state of mutual harmony. Even though human guts are more complex and these interactions are harder to detect, the revelation certainly offers new insight that could lead to medical breakthroughs, he said.
“Animal guts are similar to ours, in that they are both teeming with microbes,” said Ciche, who worked with researchers from Harvard Medical School. “These bacteria and other microorganisms are different inside their hosts than isolated in a lab, and we’re only beginning to learn how these alliances with microbes are established, how they function and how they evolve.”
The bacteria in question are bioluminescent insect pathogens. In their mutualistic state, they reside in the intestines of worms, growing slowly and performing other functions that aid nematode’s survival, even contributing to reproduction.
As the nematodes grow, the bacteria reveal their dark side. They flip a DNA switch and arm themselves by growing rapidly and producing deadly toxins. When the worms begin infesting insects, they release their bacterial insecticide.
“It’s like fleas teaming up with the plague,” Ciche said.
The question remains: What causes this dramatic transformation?
“If we can figure out why the DNA turns on and off to cause the switch between Jekyll and Hyde, we can better understand how bacteria enter stages of dormancy and antibiotic tolerance – processes critical to treating chronic infections,” Ciche said.
Part of Ciche’s research is funded by MSU AgBioResearch. Additional MSU researchers who contributed to this study include Rudolph Sloup, Alexander Martin, Anthony Heidt and Kwi-suk Kim. Scientists from the University of California-San Diego, Harvard Medical School and Yale University also contributed to this study.
Michigan State University has been working to advance the common good in uncommon ways for more than 150 years. One of the top research universities in the world, MSU focuses its vast resources on creating solutions to some of the world’s most pressing challenges, while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.
Contact: Layne Cameron, Media Communications, Office: (517) 353-8819, Cell: (765) 748-4827, Layne.Cameron@cabs.msu.edu; Todd Ciche, Microbiology and Molecular Genetics, Office: (517) 884-5359, email@example.com