Associate Professor David Harrich, from QIMR’s Molecular Virology Laboratory, has determined how to modify a protein in the virus, so that it instead provides strong, lasting protection from infection.
“This is like fighting fire with fire,” Associate Professor Harrich said.
“If this research continues down its strong path, and bear in mind there are a number of hurdles to clear, we’re looking at a cure for AIDS.”
Associate Professor Harrich runs the only research laboratory and containment facilities in Queensland working with the HIV virus.
He invented the “Nullbasic” protein by mutating an existing HIV protein. It’s shown remarkable abilities to stop the virus replicating in a lab environment.
“I have never seen anything like it. The modified protein works every time,” Assoc Prof Harrich said.
“You would still be infected with HIV, it’s not a cure for the virus. But the virus would stay latent, it wouldn’t wake up, so it wouldn’t develop into AIDS. With a treatment like this, you would maintain a healthy immune system.”
The successful development of this type of one-off treatment would also have economic implications. HIV patients currently take a regime of drugs for the rest of their lives, which can be a significant financial burden.
Associate Professor Harrich has been researching HIV for thirty years, since starting as a research assistant at the University of California, Los Angeles (UCLA) in the early 1980s when the first cases of HIV/AIDS emerged.
“I’ve come close to giving up in the past. But today I’m so encouraged. I feel very fortunate because not a lot of scientists are able to stay in the same game long enough to see these sorts of developments. It involves perseverance, dedication and, of course, sustained research funding.
Associate Professor Harrich’s research is funded by an Australian Research Council Future Fellowship.
This research is published in the current issue ofHuman Gene Therapy and can be found online at http://www.ncbi.nlm.nih.gov/pubmed/23298160
HIV FACTS: Human Immunodeficiency Virus (HIV) infects vital cells within the immune system and can cause AIDS (Acquired Immune Deficiency Syndrome). A person can be infected with the HIV virus but not have AIDS.
HIV cripples a person’s immune system, making even the most common illnesses potentially life-threatening. HIV infection occurs through the transfer of body fluids, via sexual contact, blood transfusion, sharing of needles or through the placenta from mother to unborn child.
Globally, HIV/AIDS is now a pandemic and ranks as one of the largest killers of any infectious disease. More than 25 million people have died.
The Queensland Institute of Medical Research (QIMR) is a world leading translational research institute. Our research focuses on cancer, infectious diseases, mental health and a range of complex diseases. Working in close collaboration with clinicians and other research institutes, our aim is to improve health by developing new diagnostics, better treatments and prevention strategies.
QIMR gratefully acknowledges the support of the Queensland Government.
For more information about QIMR, visitwww.qimr.edu.au