08:18pm Thursday 23 November 2017

Scientists find protein link to STI susceptibility

Ka Yee Fung, Dr Niamh Mangan and Professor Paul Hertzog

Ka Yee Fung, Dr Niamh Mangan and Professor Paul Hertzog

It is estimated that 450 million people worldwide are newly infected with STIs each year. Chlamydia has the highest infection rate of all the STIs reported in Australia.

The research, published today in the prestigious journal, Science, was led by Professor Paul Hertzog, Director of MIMR’s Centre for Innate Immunity and Infectious Diseases, and his team including, Ka Yee Fung and Niamh Mangan.

The team discovered a protein, which they called Interferon epsilon (IFNe), and showed it plays an important role in protecting females against infections. It could have clinical potential to determine which women may be more or less susceptible to disease such as STIs or to boost protective immunity.

IFNe could also be used potentially to treat STIs or other inflammatory diseases.

“One way this protein is unusual is because of the way it’s produced,” Professor Hertzog said.

“Most proteins protecting us against infection are produced only after we’re exposed to a virus or bacteria.

“But this protein is produced normally and is instead regulated by hormones so its levels change during the oestrous cycle (an animal’s menstrual cycle) and is switched off at implantation in pregnancy and at other times like menopause,” Professor Hertzog said.

“Some of these times when normal IFNe is lowest, correlate with when women are most susceptible to STIs so this might be an important link to new therapeutic opportunities – IFNe follows different rules to normal immuno-modulatory proteins, and therefore this might also be important to vaccines and the way they’re formulated to boost our protective immunity.

“Since this protein boosts female reproductive tract immune responses, it’s likely, although we haven’t addressed it directly, that this finding will be important for other infectious diseases like HIV and HPV and other diseases.”

Professor Hertzog said STIs are a critical global health and socioeconomic problem.

According to the 2011 Australian Bureau of Statistics, chlamydia has the highest infection rates of the notifiable STIs, and infection rates have more than tripled over the past decade. Men and women in the 15-19 year age group saw the largest increase in infection rates. According to these statistics, chlamydia affects more women than men, with 46,636 women aged over 15 diagnosed compared with 33,197 men aged 15 and over.

Professor Hertzog said the next step for this research would be to work towards clinical studies within the next five years. He is also keen to see whether this work can be applied across other diseases including cancer, female reproductive tract related disorders including endometriosis and pelvic inflammatory disease, as well as other non reproductive tract diseases.

This research was carried out in collaboration with partners at other departments of Monash University, and the University of Newcastle, University of Adelaide, Peter MacCallum Cancer Centre and the University of Oklahoma.

Monash University


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