08:30pm Saturday 23 September 2017

Wild mice have natural protection against Lyme borreliosis

Springtime spells tick-time. Lyme borreliosis is the most common tick-borne disease in Switzerland: around 10,000 people a year become infected with the pathogen. The actual hosts for Borrelia, however, are wild mice. Like in humans, the pathogen is also transmitted by ticks in mice. Interestingly, not all mice are equally susceptible to the bacterium and individual animals are immune to the pathogen. Scientists from the universities of Zurich and Lund headed by evolutionary biologist Barbara Tschirren reveal that the difference in vulnerability among the animals is genetic in origin.

Protective gene variant

Tschirren and colleagues examined wild mice for signs of a Borrelia infection in a large-scale field study. Borrelia afzelii – the scientific name for the bacteria – feed on mouse blood. The researchers discovered that mice with a particular variant of the antigen receptor TLR2 were around three times less susceptible to Borrelia. “The immune system of mice with this receptor variant recognizes the pathogen better and can trigger an immune response more quickly to destroy the Borrelia in time,” says Tschirren. Infected mice exhibit similar symptoms to humans – especially joint complaints. Consequently, in the wild infected mice probably do not survive for very long and weakened animals soon fall victim to foxes and birds of prey.

Arms race between mice and Borrelia

The protective gene variant is advantageous for its carriers and, according to the researchers, gradually becoming prevalent in the mouse population. Nonetheless, it is unlikely that all mice will one day be resistant to Borrelia. “The increasing resistance in the host is bound to lead to adaptations in Borrelia,” predicts Tschirren. “We can observe the evolutionary adaptation through the rearmament in mice and the pathogen.”

People also have the antigen receptor TLR2, but not the resistant gene variant observed in mice. Whether the evolutionary arms race between mice and Borrelia will have repercussions for people remains to be seen. According to Tschirren, the bacterium does not necessarily have to become more aggressive for humans.


Barbara Tschirren, Martin Andersson, Kristin Scherman, Helena Westerdahl, Peer R. E. Mittl, and Lars Råberg. Polymorphisms at the innate immune receptor TLR2 are associated with Borrelia infection in a wild rodent population. Proceedings of the Royal Society B, 20130364. April 3 , 2013. Doi: 10.1098/rspb.2013.0364

University of Zurich

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