Their results indicate that the transmission of these viruses in nature depends not only on mosquito genetic factors but also on their specific interaction with viral genetic factors. This discovery significantly advances our understanding of dengue biology in nature. From a more general standpoint, this study also refines our view of the genetic basis of host-pathogen interactions. This work was published August 01, 2013 on the PLoS Genetics website.
Genetic Mapping of Specific Interactions between Aedes aegypti Mosquitoes and Dengue Viruses, Plos Genetics, August 01, 2013
Thanyalak Fansiri (1,2), Albin Fontaine (1), Laure Diancourt (3), Valérie Caro (3), Butsaya Thaisomboonsuk (4), Jason H. Richardson (2), Richard G. Jarman (4), Alongkot Ponlawat (2) and Louis Lambrechts (1)
(1) Institut Pasteur, French National Center for Scientific Research, Associated Research Unit 3012, Paris, France.
(2) Department of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
(3) Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France.
(4) Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand