New chromosome map points the way through Campylobacter’s genetic controls

Updated on

Default Image

This information is already being used to find new genes and control mechanisms that could provide us with new ways of reducing the amount of food borne infection Campylobacter causes.

The study published in BMC Genomics has received a “Highly Accessed” accolade just two weeks after publication, an indication of its value to Campylobacter researchers across the world.

Using a high-throughput sequencing technique, Dr Ida Porcelli and colleagues at the IFR, strategically funded by BBSRC, identified in high resolution transcriptional start sites (TSS). These are the points in the genome where genes are switched on. They have then produced a map of the whole Campylobacter genome showing all of these TSS – an invaluable resource for Campylobacter researchers across the world.

From the map it is possible to get a better understanding of how Campylobacter controls its gene expression in response to different environments, and to get a better idea of how this important pathogen has evolved and adapted to become such a problem in the food chain. This knowledge is invaluable in designing new ways of reducing the burden of Campylobacter.

ENDS

 

Notes to editors

 

Read more on the Gut Health and Food Safety blog: http://blogs.ifr.ac.uk/ghfs/2013/11/campy-map

 

Reference: ‘Parallel evolution of genome structure and transcriptional landscape in the Epsilonproteobacteria‘ Porcelli I et al BMC Genomics 2013, 14:616 doi: http://dx.doi.org/10.1186/1471-2164-14-616

 

Contact

BBSRC Media Office


Tel: +44 (0)1793 414694

 

Harvard Health Publishing

Database from Health Information and Medical Information

Harvard Medical School
Go to source

Trusted Source

Database From Cleveland Clinic Foundation

Go to source

Trusted Source

Database From U.S. Department of Health & Human Services

Governmental Authority
Go to source

WHO

Database from World Health Organization

Go to source

Neurology Journals

American Academy of Neurology Journals

American Academy of Neurology
Go to source

MDPI

United Nations Global Compact
Go to source

Trusted Source

Database From National Institute for Occupational Safety & Health

U.S. Department of Health & Human Services
Go to source

Trusted Source

Database from U.S. National Library of Medicine

U.S. Federal Government
Go to source

Trusted Source

Database From Department of Health and Human Services

Governmental Authority
Go to source

PubMed Central

Database From National Institute Of Health

U.S National Library of Medicine
Go to source