This bacterium, which is naturally present in humans in the nasopharynx, is pathogenic if it reaches the blood stream. Teams led by Dr. Sandrine Bourdoulous, CNRS senior researcher at the Institut Cochin (CNRS/INSERM/Université Paris Descartes), and Professor Xavier Nassif, Institut Necker Enfants Malades (CNRS/INSERM/Université Paris Descartes/Assistance Publique – Hôpitaux de Paris), have deciphered the molecular events through which meningococci target blood vessels and colonize them. This work opens a path to new therapeutic perspectives for treating vascular problems caused by this type of invasive infection. The study was published on June 1, 2014 in Nature Medicine.
Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonisation.
Sandra C. Bernard, Nandi Simpson, Olivier Join-Lambert, Christian Federici, Marie-Pierre Laran-Chich, Nawal Maïssa, Haniaa Bouzinba-Ségard, Philippe C. Morand, Fabrice Chretien, Saïd Taouji, Eric Chevet, Sébastien Janel, Frank Lafont, Mathieu Coureuil, Audrey Segura, Florence Niedergang, Stefano Marullo, Pierre-Olivier Couraud, Xavier Nassif and Sandrine Bourdoulous. Nature Medicine. June 1, 2014.