07:47pm Sunday 17 December 2017

DNA test slashes wait times for tuberculosis diagnosis in Iqaluit

Tuberculosis continues to be a significant public health concern in Canada’s North, where testing for TB takes far longer than in the country’s major centres. A paper just published by Ottawa and Montreal researchers, in CHEST Journal, shows that the wait times before treating this infectious disease in Nunavut can be dramatically reduced by using a new technology — right in Iqaluit — that quickly provides accurate results. 

The study showed that operating a high-tech testing unit, called GeneXpert, in Iqaluit’s hospital significantly sped up diagnosis of TB, especially for those with low levels of the bacteria in their sputum. As a result, the average time to start treatment was reduced to 1.8 days, as opposed to 7.7 days for patients with high levels of TB bacteria and 37 days for those with low levels of the bacteria. 

Based on the study’s results, the Government of Nunavut has just announced funding in its 2015–2016 budget that will keep the GeneXpert operating in the territory’s capital.

“These findings represent a significant improvement in the quality of care clinicians can provide in managing this persistent and devastating disease in Canada’s North — for individual patients and for the community,” said Dr. Gonzalo Alvarez, a scientist and respirologist at The Ottawa Hospital and an associate professor at the University of Ottawa. “We are very pleased to see that the Government of Nunavut has made GeneXpert a part of its program to fight TB.”

The incidence of active tuberculosis in Nunavut remains the highest in Canada. In 2014, there were 83 residents of Nunavut treated for active TB, an infection rate 49 times the Canadian average. Despite the high rate, there is no TB laboratory capacity in Nunavut. Samples are sent to larger centres in the south for testing.

The quick test results from GeneXpert also mean that people can be quickly cleared of the disease in order to travel on a commercial airline, be released from hospital, return to work, or go to work at a camp or on a ship.

Working in partnership with the Government of Nunavut and Nunavut Tunngavik Inc., and with funding from the Government of Canada, Drs. Gonzalo Alvarez and Madhukar Pai, who is with McGill University, implemented the GeneXpert TB testing unit in Iqaluit, Nunavut, as part of a pragmatic research study that started in 2012.

GeneXpert is a desktop lab-in-a-box that identifies the presence of the TB bacteria’s genetic code. The technology has been successfully used in countries with a high burden of the disease and minimal resources. Drs. Alvarez and Pai wanted to see whether GeneXpert could provide accurate results in the real-world situation of Canada’s North as a way to reduce the wait times before starting treatment and, importantly, to minimize continued spread of the disease.

To do this, they designed a study that would test the technology in action, in which the GeneXpert unit was operated as part of the community’s hospital laboratory. In cases of suspected TB, they used the GeneXpert test and also sent sputum samples to an Ottawa lab for testing — the current practice. The lab in Ottawa performed two tests: a smear test and a culture test. When there is a lot of tuberculosis in the sample, the smear test generally catches the disease. If there isn’t, then it is diagnosed by culturing the sample, which takes longer but is the gold standard. 

One participant in the study arrived at the clinic with a chronic cough, fever and some mild weight loss. A sample was taken and the next day the GeneXpert result showed the presence of active TB. The next day the patient started intensive TB treatment and within a few days the smear test from Ottawa did not show active TB. By day 18, the cough had subsided, and the person was gaining weight and no longer had a fever. Five days later (day 23), the culture test came back positive from Ottawa. Without the GeneXpert test, this is when treatment would have started.

“It’s cases like this where GeneXpert can make the greatest difference,” said Dr. Pai, an associate director at the McGill International TB Centre. “Such quick treatment is obviously better for the patient, but it also protects the community from transmission of the disease.”

According to public health officials in Nunavut, two-thirds of all TB cases between 1999 and 2011 were only confirmed by the culture test, like the person  in the example above.

The paper “The feasibility, accuracy and impact of Xpert MTB.RIF testing in a remote Aboriginal community in Canada” was published early online on March 19, 2015, by CHEST Journal. It was funded by the Canadian Institutes of Health Research. The Government of Nunavut purchased the GeneXpert unit and provided in-kind support to house and operate it. Co-authors: Deborah D. Van Dyk, Marc Desjardins, Abdool S. Yasseen, Shawn D. Aaron, D. William Cameron, Natan Obed, Maureen Baikie, Smita Pakhale, Claudia M .Denkinger, Hojoon Sohn.

 

Partner Quotations

Minister of Health Rona Ambrose (TBC), Government of Canada

Minister Leona Aglukkaq (TBC), MP for Nunavut, Government of Canada

Minister of Health Paul Okalik (TBC), Government of Nunavut

Spokesperson TBD, Nunavut Tunngavik Inc.

 

For further information, please contact

Jenn Ganton

Communications and Public Relations

Ottawa Hospital Research Institute

jganton@ohri.ca

(o) 613-737-8899 x73325 or (c) 613-614-5253

 

 

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McGill University was founded in 1821 thanks to a generous bequest by James McGill, and since then has grown from a small college to a bustling university with two campuses, 11 faculties, some 300 programs of study, and 39,500 students. Founded in 1829, McGill’s Faculty of Medicine was the first faculty established at the University and the first medical faculty in Canada. Today, it comprises the Schools of Medicine, Physical and Occupational Therapy, and Communication Sciences and Disorders, and the Ingram School of Nursing, offering excellence in post-secondary education and research. Through the Réseau universitaire intégré de santé McGill, the Faculty of Medicine, together with its network of affiliated teaching hospitals and partners, is also responsible for coordinating access to training, research and health care for close to 1.8 million Quebecers across 63 per cent of the province’s landmass. www.mcgill.ca/medicine

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The Research Institute of the McGill University Health Centre (RI-MUHC) is a world-renowned biomedical and healthcare research centre. Located in Montreal, Quebec, Canada, the Institute is the research arm of the McGill University Health Centre (MUHC), which is affiliated with the Faculty of Medicine at McGill University. The Research Institute supports over 550 researchers, over 1,200 graduate students, post-docs and clinical fellows devoted to a broad spectrum of fundamental clinical, and health outcomes research. Over 1,900 clinical research studies are conducted within our hospitals each year. The Research Institute of the MUHC is supported in part by the Fonds de recherche du Québec – Santé (FRQS). www.muhc.ca/research/


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