07:54pm Friday 20 October 2017

Little red 'superfruit' helps ward off common infection

Cranberries in a bowl. (stock image)

Cranberries—in this case, in extract capsule form—have been found to lower the risk of urinary tract infection (UTI) by 50 percent in women who have a catheter in place while undergoing elective gynecological surgery.

The reduction in infection rates was similar to the outcome when patients take antibiotics as a preventative measure, said lead author Betsy Foxman, the Hunein F. and Hilda Maassab Endowed Professor of Epidemiology and director of the Center for Molecular and Clinical Epidemiology of Infectious Diseases at the U-M School of Public Health.

“Taking cranberry juice capsules is preferable to taking antibiotics, because limiting antibiotic use helps avoid antibiotic resistance and protects the good bacteria living in and on our bodies from inadvertent damage,” Foxman said. “We should save antibiotics for UTI treatment, as cranberry juice capsules are equally effective in preventing UTI post-elective gynecologic surgery.”

Women who undergo these procedures have as much as a 64 percent chance to develop a UTI after the catheter is removed.

For the trial, 160 study participants, ages 23-88, were divided into two groups. Half took two cranberry extract capsules twice a day for six weeks, while the other half took a placebo. All participants were recruited from the Urogynecology and Minimally Invasive Surgery clinics of the U-M Division of Gynecology.

The research is reported in the American Journal of Obstetrics and Gynecology and was funded by the National Institutes of Health.

Previous studies have shown that the cranberry has been successful at preventing urinary tract infections but this is the first to address its efficacy following surgery. The berries have not been found to work as a treatment for infections.

Cranberries are high in antioxidants, second only to blueberries, earning them the designation as a superfood or superfruit. Because of this abundance of antioxidants they have been listed as one of the foods that fights cancer. They also are high in vitamin C and dietary fiber.

The study used TheraCran cranberry capsules (Theralogix LLC), which are made using cranberry extract powder. The content of two cranberry capsules is equivalent to drinking an 8-ounce serving of cranberry juice.

Although not all women taking the cranberry supplement avoided urinary tract infections (15 out of 80 compared with 30 out of 80), the researchers found a later onset in most cases for those who were using it—18 days as opposed to 8.5 days after surgery.

An additional finding from the study was that UTI risk increased sevenfold for women who had to self-catheterize when they were unable to urinate normally after the initial catheter was removed. The length of time the catheter was in place and the number of times a woman had to self-catheterize impacted her chance for infection.

The study’s other researchers include Anna Cronenwett and Cathie Spino of the U-M School of Public Health and Dr. Mitchell Berger and Dr. Daniel Morgan of the U-M Medical School.

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