10:33am Friday 15 December 2017

New SARS-like virus can jump directly from bats to humans, no treatment available

Ralph Baric, PhD

CHAPEL HILL, NC – Researchers from the University of North Carolina at Chapel Hill have discovered a new SARS-like virus that can jump directly from its bat hosts to humans without mutation. However, researchers point out that if the SARS-like virus did jump, it is unclear whether it could spread from human to human.

The discovery, reported in Nature Medicine, is notable not only because there is no treatment for this newly discovered virus, but also because it highlights an ongoing debate over the government’s decision to suspend all gain of function experiments on a variety of select agents earlier this year. The move has substantially limited the development of vaccines or treatments for these pathogens should there be an outbreak.

“Studies have predicted the existence of nearly 5,000 coronaviruses in bat populations and some of these have the potential to emerge as human pathogens,” said senior author Ralph Baric, PhD, a professor of epidemiology at the UNC Gillings School of Global Public Health and professor of microbiology and immunology the UNC School of Medicine and world-renowned expert in coronaviruses. “So this is not a situation of ‘if’ there will be an outbreak of one of these coronaviruses but rather when and how prepared we’ll be to address it.”

SARS first jumped from animals to humans in 2002-2003 and caused a worldwide outbreak, resulting in 8,000 cases, including one case in Chapel Hill. With nearly 800 deaths during that outbreak, SARS-CoV presents much like flu symptoms but then can accelerate, compromise breathing, and bring on a deadly form of pneumonia. The outbreak was controlled through public health interventions, and the original virus was thought to have been extinct since 2004.

Baric and his team demonstrated that the newly-identified SARS-like virus, labeled SHC014-CoV and found in the Chinese horseshoe bats, can jump between bats and humans. They showed that the virus can latch onto and use the same human and bat cellular receptor for entry. The virus also replicates in primary human lung cells, the preferred target for infection.

“This virus is highly pathogenic, and treatments developed against the original SARS virus in 2002 and the ZMapp drugs used to fight Ebola fail to neutralize and control this particular virus,” Baric said. “So building resources, rather than limiting them, to both examine animal populations for new threats and develop therapeutics are key for limiting future outbreaks.”

University of North Carolina at Chapel Hill School of Medicine


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