Antibiotic resistance can work in different ways. The research described the different mechanisms of resistance as either selfish or co-operative. A selfish drug resistance only benefits the individual cell with the resistance while a co-operative antibiotic resistance benefits both the resistant cell and surrounding cells whether they are resistant or not.
The researchers analysed a plasmid called RK2 in Escherichia coli, a bacterium which can cause infectious diarrhoea. RK2 encodes both co-operative resistance to the antibiotic ampicillin and selfish resistance to another antibiotic, tetracycline. They found that selfish drug resistance is selected for at concentrations of antibiotic around 100-fold lower than would be expected – equivalent to the residues of antibiotics found in contaminated sewage outfalls.
The study, which is published in Antimicrobial Agents and Chemotherapy (AAC), involved Professor Michael Brockhurst, Dr Jamie Wood and PhD student Michael Bottery in the Departments of Biology and Mathematics at York. The work was supported by the European Research Council under the EU’s Seventh Framework Programme and the Wellcome Trust.
Dr Wood said: “The most common way bacteria become resistant to antibiotics is through horizontal gene transfer. Small bits of DNA, called plasmids, contain the resistance and can hop from one bacteria to another. Worse still, plasmids often contain more than one resistance.”
Michael Bottery added: “There is a reservoir of antibiotic resistance out there which bacteria can pick and choose from. What we have found is some of that resistance can exist at much lower concentrations of antibiotic than previously understood.”
- The paper ‘Selective conditions for a multidrug resistance plasmid depend on the sociality of antibiotic resistance’ is published in Antimicrobial Agents and Chemotherapy.
- For more information on the Department of Biology at the University of York, please visit: http://www.york.ac.uk/biology/
- For more information on the Department of Mathematics at the University of York, please visit http://maths.york.ac.uk/www/Home