01:57pm Wednesday 23 August 2017

H7N9 Influenza Virus Not Adapted to Efficient Human-to-Human Transmission

WHAT:

As of November 6, 139 confirmed human cases of avian H7N9 influenza, including 45 deaths, have been reported by the World Health Organization. Most of these cases have been linked to exposure to infected poultry, but in some cases, limited human-to-human transmission may have occurred. In this study, the TSRI scientists examined the three-dimensional structures of the hemagglutinin (HA) protein on the surface of the virus and its interaction with the human influenza receptor—the molecule on the surface of human cells that HA binds to before entering the cell and causing infection. Previous research had shown that compared to influenza viruses that are adapted to spread easily among birds, viruses adapted to humans generally have different amino acids (protein components) at the HA site that recognize and bind to the human receptor. Recent studies have shown that certain H7N9 viruses had acquired mutations that might make them more adapted to humans. However, using X-ray crystallography to study the HA and receptor structures with unprecedented accuracy, the TSRI researchers demonstrated that the HA in avian H7N9 influenza most closely resembles that of viruses that spread easily among birds, yet only weakly attaches to human influenza receptors.

Although it is not impossible that the H7N9 virus could eventually become transmissible from person to person, it would need to undergo multiple other mutations to do so, the study authors write.

ARTICLE:
R Xu et al. Preferential recognition of avian-like receptors in human influenza A H7N9 viruses. Science DOI: 10.1016/science.1243761 (2013).

WHO:
NIAID director Anthony S. Fauci, M.D., is available to discuss the findings.

CONTACT:
To schedule interviews, please contact Nalini Padmanabhan, (301) 402-1663, niaidnews@niaid.nih.gov.


NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at www.niaid.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

NIH…Turning Discovery Into Health ®


Share on:
or:

Health news