09:10pm Sunday 18 November 2018

PrEP trial leads to unprecedented reductions in HIV transmission

A global-first, UNSW-led trial of an HIV prevention medication has resulted in an almost one-third decline in infections in the large-scale target group.

Recent HIV infections in gay and bisexual men in New South Wales have declined by almost one-third following the trial of an HIV prevention medication called PrEP (Pre-Exposure Prophylaxis), according to Kirby Institute research published in The Lancet HIV on October 18.

These globally unprecedented reductions provide strong evidence to support the large-scale, targeted provision of PrEP to prevent HIV transmission.

The new research, funded by NSW Health, reports the findings from the NSW PrEP trial (called EPICNSW), which was launched in March 2016.

When taken daily, PrEP prevents HIV negative people from acquiring the virus.

The EPIC-NSW trial is the first study globally to measure the impact of PrEP on reducing HIV in a large population.

Professor Andrew Grulich from the Kirby Institute at UNSW Sydney led the trial.

“The speed of the decline we’ve seen in new HIV infections in gay and bisexual men is a world first,” said Professor Grulich.

“In the year following the trial, state-wide new HIV infections in this population decreased by one third, from 149 infections in the 12 months prior, to 102 in the 12 months after.

“These numbers are the lowest on record since HIV surveillance began in 1985.

“Our research tells us these reductions are a result of PrEP, implemented on a background of high and increasing HIV testing and treatment rates.”

The declines were highest among Australian-born gay and bisexual men (48.7%) and gay and bisexual men living in the ‘gay suburbs’ of Sydney (51.8%).

“These communities had the highest uptake of PrEP, and, in these populations, new HIV infections have halved since the trial began,” said Professor Grulich.

“However, we did not see the same reductions across the board.

“Reductions were lower in non-English speaking immigrants with a smaller 21% decline among those born in Asia.

“We need to improve education and promote access to PrEP, particularly amongst culturally and linguistically diverse men who have sex with men, and those outside the gay neighbourhoods of Sydney.”

NSW was the first state in Australia to trial PrEP at a large scale.

The EPIC-NSW trial enrolled 9,714 HIV negative people at high risk of HIV and provided them with PrEP.

The study ceased enrolling on the 30 April 2018, following PrEP being made available through the Pharmaceutical Benefits Scheme.

“Now that PrEP has been listed on the PBS, and is available across Australia, we need to focus our attention on ensuring equitable access for all people at risk of HIV,” said Professor Grulich.

Professor Grulich credits the success of EPIC-NSW to a collaborative approach and the commitment of multiple partners across clinics, community and researchers, as well as leadership from the NSW government.

Dr Kerry Chant, the NSW Chief Health Officer also highlighted the importance of collaboration.

“NSW has a long history of successful partnerships in HIV prevention,” said Dr Chant.

“It’s these partnerships that have led to the success of EPIC-NSW and serve as a blueprint for other states and countries aiming to eliminate HIV transmission.

“The results from EPIC-NSW provide an important evidence-base to inform our response to HIV globally,” added Professor Grulich.

“We now know that PrEP implemented quickly, at a large scale, and targeted to high-risk populations can help turn the HIV epidemic around.”

Professor Andrew Grulich is available for interviews.

About the Kirby Institute

The Kirby Institute at UNSW Sydney is one of Australia’s leading infectious diseases research institutes. Based in Sydney, the Kirby Institute is funded by the Australian Government to conduct research into HIV, viral hepatitis, bloodborne viruses, and sexually transmissible infections in Australia. The primary work of the Institute relates to the coordination of national surveillance programs, population health and epidemiological research, clinical and behavioural research and clinical trials. The Kirby Institute is affiliated with UNSW Medicine.

 

UNSW Sydney

 


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