The mutation works by enhancing VRC01’s ability to bind to a cellular protein that prevents the antibody from degrading inside cells and influences how frequently the antibody reaches mucosal surfaces and stays there, the researchers report. This finding may inform antibody-based prevention strategies against not only HIV but also other viruses that invade the body at mucosal surfaces, including rotavirus, poliovirus, norovirus and influenza virus.
S-Y Ko, et al. Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. Nature DOI: 10.1038/nature13612 (2014).
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