10:34am Saturday 21 October 2017

Anti-HIV Antibody Shows Promise in First Human Study

Major funding for the research was provided by the Bill and Melinda Gates Foundation, The Rockefeller University, and supported in part by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the NIH. The research was led by long-time NIAID grantee Michel C. Nussenzweig, M.D., Ph.D., of the Howard Hughes Medical Institute at The Rockefeller University in New York City.

Before its first-in-human testing, the 3BNC117 antibody had neutralized many diverse HIV strains in laboratory tests and had protected humanized mice and macaques from HIV and its simian equivalent. To determine if the investigational product would be safe and potentially effective in people, the research team conducted a small clinical trial among 29 volunteers, 17 HIV-infected and 12 uninfected individuals. Study participants received a single intravenous dose of 3BNC117 of 1, 3, 10 or 30 milligrams. The investigational product was well-tolerated by all participants. Among HIV-infected participants, 3BNC117 had the greatest effect on the eight participants who received the highest dose, resulting in significant and rapid decreases in viral load. HIV resistance to 3BNC117 was variable, but some individuals remained sensitive to the antibody for 28 days.

Based on the findings, the authors conclude that 3BNC117 is safe in people and can have a substantial effect on controlling HIV levels and should, therefore, be explored further for use in HIV prevention and treatment. Additionally, in the future the investigational antibody may be used to help eradicate HIV from latent reservoirs in an infected person’s body, according to the authors.

ARTICLE:
Marina Caskey et al. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature DOI: 10.1038/nature14411 (2015).

WHO:
NIAID Director Anthony S. Fauci, M.D., is available for comment.

CONTACT:
To schedule interviews, please contact Robin Tricoles, (301) 402-1663, niaidnews@niaid.nih.gov.


NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.

About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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