Lower levels of cholesterol in certain immune cells—a result of enhanced cholesterol metabolism within those cells—may help explain why some HIV-infected people are able to naturally control disease progression, according to research that will be presented in a poster at the 8th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015) in Vancouver, Canada, and the pre-conference 2015 Towards an HIV Cure Symposium. The findings provide a basis for potential development of new approaches to control HIV infection by regulating cellular cholesterol metabolism.
G Rappocciolo et al. Profound alterations in cholesterol metabolism restrict HIV-1 trans infection of CD4 T cells in nonprogressors. Program number MOPEA013, Track A.
NIAID Director Anthony S. Fauci, M.D., is available for comment.
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