02:15pm Thursday 09 July 2020

Advance in the treatment of HIV by prototype vaccine vector

HIV vaccine vectors

A team of scientists at Royal Holloway, led by Professor George Dickson, and as part of the UK HIV Vaccine Consortium, led by Professor Jonathon Weber at Imperial College London, has developed a prototype HIV vaccine vector using a similar approach to that used for a vaccination for Ebola and Malaria.

According to the World Health Organisation, more than 35 million people are living with HIV/ AIDS or almost 1% of all adults aged 15-49. Over two million people are newly infected every year, and it is estimated that globally around £10 billion is spent each year on HIV treatment and care.

Although researchers have been working on developing a vaccine for 30 years, recent advances are helping to speed up their quest and by pooling their knowledge the scientists have made progress with a new vaccine prototype which they hope can be taken through to human trials. The team’s findings are published in the journal Vaccine.

Professor Dickson, from the School of Biological Sciences, at Royal Holloway, said: “Discovery of an effective vaccine against HIV is one of the greatest challenges in medical research. Our work makes a contribution to the growing and profound body of knowledge about the nature of protective immune responses required for an effective AIDS vaccine. But success will require multidisciplinary efforts like the UK HVC to take discoveries in the lab onwards through preclinical testing and manufacture, into early human trials.”

Dr Shan Herath and Dr Anita Le Heron are key members of the Royal Holloway research team working on the verified prototype HIV vaccine vector project which was funded by the Wellcome Trust.

They have engineered two Chimpanzee adenovirus vaccine vectors (chAd3 and chAd63) to express recombinant HIV proteins. They have studied the immune responses to the vaccines and shown reactions to different parts of the HIV transgene. A comparison of the different vaccines also shows differences in efficacy between different vectors and this is of interest when trying to understand how vaccines work. The results suggest that chimpanzee adenoviruses are good candidates as viral vectors for potential HIV vaccines.

Royal Holloway, University of London
TW20 0EX

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