Higher strength statins do not increase risk of kidney injury

Updated on - Written by

Study Highlights:

  • A higher strength of  cholesterol-lowering drugs called statins did not increase the risk of kidney injury after heart attack.
  • These findings may reassure doctors and patients of the safety of higher strength statins among heart attack survivors.

Statins have been shown to reduce the risk of a first or recurrent heart attack, but recent observational studies suggest that high doses may be linked to a higher incidence of kidney injury.

In this study, researchers analyzed data from two large clinical trials in which survivors were randomly assigned to receive either high- or low-dose statins. Higher strenght statins did not increase the risk of hospitalizations with kidney injury when compared to low-dose statins.  In addition, concentrations of a blood protein, called creatinine, which reflects kidney function were comparable between the two groups during follow-up.

“These findings provide important reassurance to clinicians that the use of some high-potency statins will not increase the risk of kidney injury,” said Amy Sarma, M.D., M.H.S., the study’s lead author and a resident physician in internal medicine at Brigham and Women’s Hospital in Boston, Mass.

The study data were obtained from two trials with more than 4,000 participants each – the PROVE IT-TIMI 22, and the A-to-Z Trial.

Co-authors are Christopher P. Cannon, M.D.; Stephen D. Wiviott, M.D.; Marc S. Sabatine, M.D., M.P.H.; Marc A. Pfeffer, M.D., Ph.D.; Elaine B. Hoffman. Ph.D.; Jianping Guo, M.A.S. and James A. de Lemos, M.D.  The senior author was Michelle L. O’Donoghue, M.D., M.P.H.

Author disclosures are on the abstract. Bristol-Myers Squibb and Sankyo funded the PROVE IT-TIMI 22 study. Merck funded the A-to-Z trial.

For the latest heart and stroke news, follow @HeartNews on Twitter.

###

Statements and conclusions of study authors published in American Heart Association scientific journals or presented at American Heart Association conferences are solely those of the study authors and do not necessarily reflect the association’s policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at www.heart.org/corporatefunding.

Additional resources, included multimedia, are available in the right column of this link: http://newsroom.heart.org/news/higher-strength-statins-do-not-increase-risk-of-kidney-injury?preview=8c429a7ef3e87bc71de0dfd62883fc43

For Media Inquiries: (214) 706-1173
Maggie Francis: (214) 706-1382; [email protected]
Carrie Thacker: (214) 706-1665; [email protected]
Julie Del Barto (broadcast): (214) 706-1330; [email protected]
For Public Inquiries: (800) AHA-USA1 (242-8721)
This research is part of the American Heart Association’s
Emerging Science Series, a free online webinar presentation.
View the webinar at www.scientificsessions.org/emergingscience.

 


+ sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

Written by:

Healthcanal Staff

Medically reviewed by:

HealthCanal Editorial team is a team of high standard writers, who qualified the strict entrance test of Health Canal. The team involves in both topic researching and writting, which are under supervision and controlled by medical doctors of medical team.

PubMed Central

Database From National Institute Of Health

U.S National Library of Medicine
Go to source