11:35pm Tuesday 22 October 2019

Aerobic exercise capacity linked to stronger hearts, longer life

Aerobic exercise capacity has proven to be a good indicator of health.

But a recent paper in Circulation Research whose authors include researchers from the Norwegian University of Science and Technology’s KG Jebsen Center of Exercise and Medicine and the University of Michigan System uses a rat model to show that innate exercise capacity can be linked to longevity.

Low aerobic exercise capacity is a strong predictor of premature morbidity and mortality in both healthy adults and people with cardiovascular disease.

In the elderly, poor performance on treadmill or extended walking tests indicates proximity to future health decline. In order to test the association between aerobic exercise capacity and survivability, a rat model was made through artificial selective breeding.

Laboratory rats of widely varying genetic backgrounds were bred for low or high intrinsic treadmill running capacity. Rats from multiple generations were followed for survivability and assessed for age-related declines in cardiovascular fitness, such as peak oxygen uptake, myocardial function, endurance performance and change in body mass.

“We found that the average lifespan of rats with innate low exercise capacity was 28 percent to 45 percent shorter than for rats with an inborn high exercise capacity,” authors write. “Likewise, the peak oxygen uptake measured across adulthood was a reliable predictor of lifespan.”

As they transitioned to old age, rats with an inborn low capacity for exercise had worse cardiac health by multiple measures such as left ventricular myocardial and cardiomyocyte morphology, mean blood pressure, and intracellular calcium handling in both systole and diastole.

Moreover, rats with high innate exercise capacities had better sustained physical activity levels, energy expenditures, and lean body mass with age than their low-capacity cohorts.

Since the rats came from a wide variety of backgrounds, authors concluded, the results provide strong evidence that innate capacity for exercise can be linked to longevity, thus aerobic exercise capacity can prove useful in future exploration of the mechanisms behind cardiovascular disease.


U-M Authors: lead author Lauren Gerard Koch, Ph.D., associate professor of anesthesiology; Nathan Qi, Ph.D., assistant research professor metabolism, endocrinology and diabetes; and Charles F. Burant, M.D., Ph.D., professor of internal medicine.

Reference: “Instrisic aerobic capacity sets a divie for aging and longevity,” Circulation Research, Sept. 15, 2011.

Press release courtesy of Norwegian University of Science and Technology.

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